Supprelin-LA

Generic name: Histrelin (implant)

Usage of Supprelin-LA

Supprelin LA is a man-made form of a hormone that regulates many processes in the body. Histrelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.

Supprelin LA implants are used to treat precocious puberty in both male and female children who are at least 2 years old.

Supprelin LA may also be used for purposes not listed in this medication guide.

Supprelin-LA side effects

Get emergency medical help if you have signs of an allergic reaction to Supprelin LA: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bone pain, numbness or weakness in your legs or feet;
  • painful or difficult urination, blood in your urine;
  • a seizure;
  • increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
  • mental problems - crying spells, anger, aggression, feeling restless or irritable.

    • Common Supprelin LA side effects may include:

  • constipation;
  • urination problems;</<p>
  • breast swelling;</<p>
  • hot flashes;</<p>
  • feeling tired;</<p>
  • erectile dysfunction (impotence), decreased testicle size; or</<p>
  • pain, redness, bruising, swelling, or skin irritation where the implant was inserted.</<p>

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    How to use Supprelin-LA

    Usual Pediatric Dose for Precocious Puberty:

    One 50 mg implant inserted suBCutaneously in the inner aspect of the upper arm Duration of therapy: The implant should be removed after 12 months. Comments: -To continue therapy, another implant may be inserted at the time an implant is removed. -Discontinuation of therapy should be considered at the discretion of the physician and at the appropriate time point for the onset of puberty (approximately 11 years for females and 12 years for males). Use: Treatment of children with central precocious puberty

    Warnings

    Supprelin LA can harm an unborn baby or cause a miscarriage. Do not use if you are pregnant.

    Supprelin LA can cause side effects such as crying spells, anger, aggression, and feeling restless or irritable. Call your doctor if you have any new or worsening mental problems.

    Before you receive Supprelin LA, tell your doctor if you have painful or difficult urination, diabetes, heart disease, coronary artery disease, liver disease, a history of heart attack or stroke, osteoporosis, or a condition affecting your spine.

    Call your doctor at once if you have a serious side effect such as severe numbness or tingling in your legs or feet, muscle weakness, problems with balance or coordination, loss of bladder or bowel control, urinating more or less than usual, sudden numbness or severe headache, problems with speech or vision, increased thirst or urination, excessive hunger, or chest pain spreading to the arm or shoulder.

    A Supprelin LA implant is usually left in place for 12 months and then removed. Your doctor will determine at that time whether you need to receive another implant for treatment of your symptoms.

    What other drugs will affect Supprelin-LA

    Other drugs may interact with histrelin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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