Syfovre
Generic name: Pegcetacoplan
Dosage form: intravitreal injection
Drug class:
Miscellaneous ophthalmic agents
Usage of Syfovre
Syfovre (pegcetacoplan) injection is used to treat geographic atrophy (GA), which is the dry advanced form of age-related macular degeneration (AMD). Syfovre is a complement inhibitor that works to slow the growth of GA lesions, to help preserve vision by reducing more significant vision loss and blindness.
Syfovre is the first and only FDA approved for the treatment of geographic atrophy secondary to age-related macular degeneration.
Geographic atrophy lesions are areas in the retina that are damaged due to age-related macular degeneration. Over time the geographic atrophy lesion(s) become larger and can spread to the center of the retina (fovea), which is the area that is most important for the sharpest vision. It is the progression of the lesion over the fovea that causes vision loss and blindness.
Syfovre injections have been shown in Phase 3 OAKS clinical trial and Phase 3 Derby studies to slow the growth and spread of GA lesions, which can help preserve vision.
Syfovre side effects
Common side effects of Syfovre include:
Serious side effects of Syfovre include:
Eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment)
Risk of developing wet AMD.
Episodes of eye inflammation.
Increase in eye pressure within minutes of the injection.
These are not all the possible side effects of this medicine.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before taking Syfovre
Tell your healthcare provider if:
Pregnancy
Tell your doctor if you are pregnant or planning to become pregnant.
Women able to become pregnant should use effective contraception methods to prevent pregnancy during treatment with this medicine and for 40 days after the last dose. For women planning to become pregnant, the use of Syfovre may be considered following an assessment of the risks and benefits.
Breastfeeding
Ask your doctor for advice before taking this medicine if you are breastfeeding or planning to breastfeeding, your doctor will talk to you about about the best way to feed your baby.
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Warnings
You should NOT receive Syfovre if you:
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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