Sylvant
Generic name: Siltuximab
Drug class:
Interleukin inhibitors
Usage of Sylvant
Sylvant inhibits a certain protein in the body called interleukin-6 (IL-6). High levels of IL-6 can cause an overgrowth of cells in the lymph system (part of your immune system).
Sylvant is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.
Sylvant is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.
Sylvant side effects
Get emergency medical help if you have any signs of an allergic reaction to Sylvant: hives; chest tightness, difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel nauseated, or have back pain, warmth or redness under your skin, chest pain, pounding heartbeats, fluttering in your chest, or swelling in your face.
Call your doctor at once if you have:
Common Sylvant side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Sylvant
You should not be treated with Sylvant if you are allergic to siltuximab, or if you have a severe infection.
If you have a severe illness with fever or any type of infection, you may need to wait until you get better before receiving this medicine. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
To make sure Sylvant is safe for you, tell your doctor if you have ever had:
Sylvant may harm an unborn baby. Siltuximab an affect the immune system of a newborn if the mother receives the medicine during pregnancy. Uee effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.
You should not breast-feed while using this medicine.
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How to use Sylvant
Usual Adult Dose for Castleman's Disease:
11 mg/kg intravenously over 1 hour every 3 weeks. Duration of therapy: Until treatment failure. Comments: -Siltuximab was not studied in patients with MCD who are HIV positive or HHV-8 positive because siltuximab did not bind to virally produced IL-6 in a nonclinical study. Use: Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.
Warnings
You should not use Sylvant if you have a severe infection. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).
What other drugs will affect Sylvant
Other drugs may interact with siltuximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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