Sylvant

Generic name: Siltuximab
Drug class: Interleukin inhibitors

Usage of Sylvant

Sylvant inhibits a certain protein in the body called interleukin-6 (IL-6). High levels of IL-6 can cause an overgrowth of cells in the lymph system (part of your immune system).

Sylvant is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.

Sylvant is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.

Sylvant side effects

Get emergency medical help if you have any signs of an allergic reaction to Sylvant: hives; chest tightness, difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel nauseated, or have back pain, warmth or redness under your skin, chest pain, pounding heartbeats, fluttering in your chest, or swelling in your face.

Call your doctor at once if you have:

  • bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds;
  • signs of infection, such as fever, chills, painful mouth sores, pain when swallowing, cold or flu symptoms, cough, trouble breathing; or
  • signs of a kidney problem - little or no urination; painful or difficult urination; swelling in your feet or ankles; severe pain in your side or lower back.
  • Common Sylvant side effects may include:

  • weight gain;
  • itching or rash;
  • cold symptoms such as stuffy nose, sneezing, sore throat; or
  • high levels of uric acid in your blood (can lead to kidney problems or gout symptoms such as joint stiffness, pain, or swelling).
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Sylvant

    You should not be treated with Sylvant if you are allergic to siltuximab, or if you have a severe infection.

    If you have a severe illness with fever or any type of infection, you may need to wait until you get better before receiving this medicine. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).

    To make sure Sylvant is safe for you, tell your doctor if you have ever had:

  • a chronic infection;
  • a stomach or intestinal disorder, including ulcer or diverticulitis;
  • stomach or intestinal bleeding;
  • gout; or
  • if you have recently received any vaccines, or if you are due to receive one.
  • Sylvant may harm an unborn baby. Siltuximab an affect the immune system of a newborn if the mother receives the medicine during pregnancy. Uee effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

    You should not breast-feed while using this medicine.

    Relate drugs

    How to use Sylvant

    Usual Adult Dose for Castleman's Disease:

    11 mg/kg intravenously over 1 hour every 3 weeks. Duration of therapy: Until treatment failure. Comments: -Siltuximab was not studied in patients with MCD who are HIV positive or HHV-8 positive because siltuximab did not bind to virally produced IL-6 in a nonclinical study. Use: Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

    Warnings

    You should not use Sylvant if you have a severe infection. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).

    What other drugs will affect Sylvant

    Other drugs may interact with siltuximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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