Symfi

Generic name: Efavirenz, Lamivudine, And Tenofovir
Drug class: Antiviral combinations

Usage of Symfi

Symfi contains a combination of efavirenz, lamivudine, and tenofovir. Efavirenz, lamivudine, and tenofovir are antiviral medicines that prevents human immunodeficiency virus human immunodeficiency virus (HIV) from multiplying in your body.

HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Symfi is for use in adults and children who weigh at least 88 pounds (40 kilograms).

Symfi Lo is for use in adults and children who weigh at least 77 pounds (35 kilograms).

Symfi side effects

Get emergency medical help if you have signs of an allergic reaction ro Symfi (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe dizziness or drowsiness, trouble concentrating, strange dreams;
  • confusion, thinking problems, seeing or hearing things that are not real (may occur months to years after you start taking this medicine);
  • fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);
  • problems with balance or coordination;
  • new or worsening bone pain;
  • pain in your arms, legs, hands, or feet;
  • lactic acidosis - unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired;
  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • unusual thoughts - fear, paranoia, feeling sad or hopeless, thoughts of hurting yourself or others; or
  • liver problems - swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
  • Symfi affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
  • Common Symfi side effects may include:

  • headache, dizziness;
  • depression, thinking problems;
  • nausea, diarrhea;
  • sleep problems (insomnia);
  • pain;
  • weakness, tiredness;
  • cough, stuffy nose, sinus pain;
  • rash; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Symfi

    You should not use Symfi if:

  • you also take elbasvir and grazoprevir (for hepatitis C); or
  • you are allergic to any antiviral combination medicine that contains efavirenz, lamivudine, or tenofovir.
  • To make sure Symfi is safe for you, tell your doctor if you have ever had:

  • liver disease (especially hepatitis B or C); or
  • kidney disease (or if you are on dialysis);
  • heart problems;
  • long QT syndrome (in you or a family member);
  • drug or alcohol addiction;
  • a seizure; or
  • fractures or other problems with your bones.
  • You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you are overweight or if you are a woman. Ask your doctor about your risk.

    You may need to have a negative pregnancy test before starting this treatment.

    Do not use Symfi if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 12 weeks after your last dose.

    Use two forms of birth control to prevent pregnancy, including a barrier form such as a condom, diaphragm, cervical cap, or contraceptive sponge.

    If you are pregnant, your name may be listed on a pregnancy registry to track the effects of Symfi on the baby.

    Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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    How to use Symfi

    Usual Adult Dose for HIV Infection:

    1 tablet orally once a day Use: As a complete regimen for the treatment of HIV-1 infection

    Usual Pediatric Dose for HIV Infection:

    1 tablet orally once a day Comments: -Symfi Lo is approved for patients weighing at least 35 kg. -Symfi is approved for patients weighing at least 40 kg. -Recommended for pediatric patients who can swallow a solid tablet Use: As a complete regimen for the treatment of HIV-1 infection

    Warnings

    Symfi may cause a serious condition called lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

    Call your doctor at once if you have swelling or pain in your upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, or yellowing of the skin or eyes.

    Symfi may cause serious mental health problems. Get medical help if you have unusual sadness, paranoia, hallucinations, or thoughts about hurting yourself or others.

    If you've ever had hepatitis B, it may become active or get worse after you stop using Symfi. You may need frequent liver function tests for several months.

    Do not change your dose or stop taking this medicine without your doctor's advice.

    What other drugs will affect Symfi

    Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

    Many drugs can interact with efavirenz, lamivudine, and tenofovir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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