Synvisc-One

Generic name: Hylan G-F 20
Drug class: Viscosupplementation agents

Usage of Synvisc-One

Synvisc-One is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.

Synvisc-One is used to treat knee pain caused by osteoarthritis. It is usually given after other arthritis medications have been tried without successful treatment of symptoms.

Synvisc-One may also be used for purposes not listed in this medication guide.

Synvisc-One side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Synvisc-One: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe pain or swelling around the knee after the injection.

Less serious Synvisc-One side effects may include:

  • warmth, pain, stiffness, swelling, or puffiness where the medicine was injected;
  • muscle pain, trouble walking;
  • fever, chills, nausea;
  • numbness or tingly feeling;
  • headache, dizziness;
  • tired feeling; or
  • itching or skin irritation around the knee.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Synvisc-One

    You should not receive Synvisc-One if you are allergic to hylan G-F 20, or if you have an infection in your knee or in the skin around your knee.

    To make sure you can safely receive Synvisc-One, tell your doctor if you have:

  • blood clots or circulation problems in your legs; or
  • an allergy to birds, feathers, or egg products.

    • It is not known whether Synvisc-One will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

    It is not known whether Synvisc-One passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Synvisc-One is generally not used in anyone younger than 21 years old.

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    How to use Synvisc-One

    Usual Adult Dose for Osteoarthritis: Synvisc-One is administered as a single intra-articular injection. Strict aseptic administration technique must be followed.

  • Inject the full 6 mL in one knee only.
  • Using an 18 to 20 gauge needle, remove synovial fluid or effusion before injecting Synvisc-One.
  • Do not use the same syringe for removing synovial fluid and for injecting Synvisc-One.
  • Twist the tip cap before pulling it off, as this will minimize product leakage.
  • To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub.

    • Warnings

    You should not receive Synvisc-One if you are allergic to hylan G-F 20, or if you have an infection in your knee or in the skin around your knee.

    Before you receive a Synvisc-One injection, tell your doctor if you have blood clots or circulation problems in your legs, or an allergy to birds, feathers, or egg products.

    For at least 48 hours after your injection, avoid jogging, strenuous activity, high-impact sports, or standing for longer than 1 hour at a time.

    Call your doctor at once if you have severe pain or swelling around the knee after the injection.

    What other drugs will affect Synvisc-One

    There may be other drugs that can interact with Synvisc-One. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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