Talazoparib

Generic name: Talazoparib
Brand names: Talzenna
Dosage form: oral capsule (0.1 mg; 0.25 mg; 0.35 mg; 0.5 mg; 0.75 mg; 1 mg)
Drug class: PARP inhibitors

Usage of Talazoparib

Talazoparib is used in adults to treat certain type of breast cancer that has spread to other parts of the body.

Talazoparib is also used in adults in combination with other drugs to treat prostate cancer that has spread to other parts of the body and when surgery or other treatments to decrease Testosterone levels have not worked.

Your doctor will make sure you have the correct tumor type to be treated with talazoparib.

Talazoparib may also be used for purposes not listed in this medication guide.

Talazoparib side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Talazoparib may cause serious side effects. Call your doctor at once if you have:

blood in your urine or stools;

easy bruising, unusual bleeding, purple or red spots under your skin;

weight loss;

frequent infections;

low red blood cells (anemia)--pale skin, weakness, tiredness, feeling light-headed or short of breath, cold hands and feet; or

low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of talazoparib may include:

low blood cell counts;

an electrolyte imbalance (such as low blood levels of potassium or Magnesium);

bone injuries, low levels of calcium in your blood (hypocalcemia);

high levels of bilirubin in the blood;

high blood sugar;

changes in your sense of taste

nausea, vomiting, diarrhea, loss of appetite;

hair loss;

dizziness, headache; or

feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Talazoparib

Tell your doctor if you have or have ever had:

kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about your individual risk.

Talazoparib can harm an unborn baby if the mother or the father is using talazoparib.

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 7 months after your last dose.

If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

Tell your doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Relate drugs

How to use Talazoparib

Usual Adult Dose for Breast Cancer:

1 mg orally once a day until disease progression or uNACceptable toxicityComments:-Select patients based on the presence of germline BRCA mUTAtions as determined by an FDA-approved test.Use: For the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer

Warnings

Using talazoparib may increase your risk of developing bone marrow problems or leukemia.

Talazoparib can lower your blood cell counts, and you may get infections or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, weight loss, fever, weakness, tiredness, or trouble breathing.

Your blood will be tested before and during treatment and your cancer treatments may be delayed based on the results.

What other drugs will affect Talazoparib

Tell your doctor about all your other medicines, especially:

amiodarone;

Carvedilol;

clarithromycin;

itraconazole; or

verapamil.

This list is not complete. Other drugs may affect talazoparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.