Taltz

Generic name: Ixekizumab
Drug class: Interleukin inhibitors

Usage of Taltz

Taltz (ixekizumab) is an injectable medicine used to treat plaque psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis, which are all autoimmune disorders. Taltz works by reducing inflammation which helps improve the symptoms of these conditions.

Taltz is a monoclonal antibody that acts by binding and Neutralizing a naturally occurring protein called interleukin 17A (IL-17A). This protein is involved in inflammation and how the immune system responds. When Taltz binds to the protein, inflammation is reduced, and this improves symptoms of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis.

Taltz side effects

Common Taltz side effects may include nausea, ear infection, cold symptoms such as stuffy nose, sneezing, sore throat, and also pain or redness where the medicine was injected,

Serious Taltz side effects

Allergic Reaction: Immediately get emergency medical help if you have signs of an allergic reaction such as rash, chest tightness, or difficulty breathing. feeling like you might pass out, swelling of your face, eyelids, lips, mouth, tongue, or throat.

Taltz may cause other serious side effects

Call your doctor at once if you have:

fever, chills, sweating, muscle pain, weight loss;

diarrhea (may be bloody), stomach cramps;

painful skin sores;

cough, shortness of breath, cough with red or pink mucus;

sores or white patches in your mouth or throat (yeast infection or "thrush");

increased urination, pain or burning when you urinate;

eye swelling, redness, crusting or drainage (may be signs of infection); or

signs of a fungal infection (rash or red patches, itching, burning, cracked skin, hair loss).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Taltz

You should not use this medicine if you are allergic to the active ingredient ixekizumab, or any of the inactive ingredients contained in this medicine. To check for a complete list of ingredients click here: Taltz ingredients.

To make sure Taltz is safe for you, tell your doctor if you have:

an active or recent infection;

Crohn's disease, ulcerative colitis;

tuberculosis (or if you have close contact with someone who has tuberculosis): or.

if you have recently received or are scheduled to receive a vaccine.

Your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Make sure you are up to date with all age-appropriate vaccinations before you start treatment with this medicine.

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant . It is not known if Taltz can harm your unborn baby. If you are pregnant or you become pregnant, your name may be listed on a pregnancy registry to track the effects of ixekizumab on the baby. The purpose of this registry is to collect information about the health of you and your baby.

Breastfeeding

Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby.

Relate drugs

How to use Taltz

Usual Adult Dose for Plaque Psoriasis

160 mg (two 80 mg injections) suBC UTAneously at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks.

Use: For the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Usual Pediatric Dose for Plaque Psoriasis

Weight less than 25 kg. Dose 40 mg subcutaneously at Week 0, followed by 20mg every 4 weeks thereafter.

Weight 25 to 50 kg. Dose 80 mg subcutaneously at Week 0, followed by 40mg every 4 weeks thereafter.

Weight greater than 50 kg. Dose 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80mg every 4 weeks thereafter.

Use: For the treatment of pediatric patients from 6 years of age to less than 18 years of age with moderate-to-severe plaque psoriasis

Usual Adult Dose for Psoriatic Arthritis

160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks

For psoriatic arthritis patients with coexistent moderate-to-severe plaque psoriasis, use the dosing regimen for plaque psoriasis.

This drug may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (cDMARD) (e.g., methotrexate).

Use: For the treatment of adult patients with active psoriatic arthritis

Usual Adult Dose for Ankylosing Spondylitis

160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks.

Usual Adult Dose for Non-radiographic Axial Spondyloarthritis

160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks.

Warnings

Infections. This medicine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, sweating, muscle pain, weight loss, skin sores, shortness of breath, cough with red or pink mucus, increased urination, or painful urination.

Tuberculosis. Your doctor may perform tests to make sure you do not have tuberculosis or other infections

Hypersensitivity. Serious hypersensitivity reactions can occur with this medicine. If an allergic reaction occurs discontinue treatment immediately and initiate appropriate therapy. Taltz is contraindicated in patients who have had previous serious hypersensitivity reaction to this medicine.

Immunization. You should not have live vaccines while being treated with this medicine.

Inflammatory bowel disease. Crohn's disease and ulcerative colitis, including exacerbations have occurred during treatment with this medicine. Patients should be monitored closely when this medicine is prescribed to patients with inflammatory bowel disease (IBD). If IBD develops and appropriate medical management should be started.

What other drugs will affect Taltz

Other drugs may interact with this medicine including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

It is important to tell your doctor if you take any of these medicines:

Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril)

cyclosporine (Gengraf, Neoral, Sandimmune)

Quinidine (in Nuedexta)

sirolimus (Rapamune)

tacrolimus (Astagraf, Envarsus, Prograf)

Warfarin (Coumadin, Jantoven)

Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with Taltz so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. To check for interactions with Taltz click on the link below.

Disclaimer

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