Tazemetostat

Generic name: Tazemetostat
Brand names: Tazverik
Dosage form: oral tablet (200 mg)
Drug class: Miscellaneous antineoplastics

Usage of Tazemetostat

Tazemetostat is used to treat advanced epithelioid sarcoma, a rare slow-growing type of soft tissue cancer. tazemetostat is used when the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery.

Tazemetostat is for use in adults and children at least 16 years old.

Tazemetostat was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Tazemetostat may also be used for purposes not listed in this medication guide.

Tazemetostat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tazemetostat may cause serious side effects. Call your doctor at once if you have:

unusual tiredness;

bone pain; or

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of tazemetostat may include:

nausea, vomiting, loss of appetite;

constipation;

pain; or

tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Tazemetostat

Using tazemetostat may increase your risk of developing bone marrow disorders or other cancers, such as leukemia or lymphoma. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Tazemetostat can harm an unborn baby or cause birth defects if the mother or the father is using tazemetostat.

If you are a woman, do not use tazemetostat if you are pregnant. Use effective nonhormonal birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.

Tazemetostat can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using tazemetostat, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Relate drugs

How to use Tazemetostat

Usual Adult Dose for Soft Tissue Sarcoma:

800 mg orally twice dailyDuration: Until disease progression or unacceptable toxicity.Uses: For the treatment of adult patients with, metastatic or locally advanced epithelioid sarcoma not eligible for complete resection

Usual Adult Dose for Follicular Lymphoma:

800 mg orally twice dailyDuration: Until disease progression or unacceptable toxicity.Comment:Select patients with relapsed or refractory (R/R) follicular lymphoma (FL) based on the presence of EZH2 mUTAtion.Uses: For the treatment of adult patients with, relapsed or refractory follicular lymphoma whose tumors are positive for an EZH2 mutation and who have received at least 2 prior systemic therapies or who have no satisfactory alternative treatment options

Usual Pediatric Dose for Soft Tissue Sarcoma:

16 years and older:800 mg orally twice dailyDuration: Until disease progression or unacceptable toxicity.Use: For the treatment of pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection

Warnings

Using tazemetostat may increase your risk of developing bone marrow disorders or other cancers. Tell your doctor if you feel unusually tired or have a fever, pale skin, easy bruising, or bone pain.

What other drugs will affect Tazemetostat

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect tazemetostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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