Thalitone

Generic name: Chlorthalidone
Drug class: Thiazide diuretics

Usage of Thalitone

Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Chlorthalidone is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a hormone or steroid medicine.

Chlorthalidone is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure.

This medicine is available only with your doctor's prescription.

Thalitone side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

bloating

blood in the urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

chills

clay-colored stools

cold sweats

confusion

cough or hoarseness

coughing up blood

darkened urine

diarrhea

difficulty having a bowel movement (stool)

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

fast heartbeat

fever

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

increased hunger

increased thirst

increased urination

indigestion

itching or skin rash

joint pain, stiffness, or swelling

loss of appetite

lower back or side pain

nausea

pain in the joints or muscles

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pinpoint red spots on the skin

red, irritated eyes

red skin lesions, often with a purple center

redness, soreness or itching skin

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sores, welting, or blisters

sugar in the urine

sweating

swelling of the feet or lower legs

swollen glands

tightness in the chest

troubled breathing

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight loss

vomiting

vomiting of blood

weight loss

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Cramping

decreased interest in sexual intercourse

feeling of constant movement of self or surroundings

hives

inability to have or keep an erection

increased sensitivity of the skin to sunlight

loss in sexual ability, desire, drive, or performance

muscle spasm

redness or other discoloration of the skin

restlessness

sensation of spinning

severe sunburn

weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Thalitone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of chlorthalidone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlorthalidone in the elderly. However, elderly patients are more likely to have age-related kidney disease, which may require caution and an adjustment in the dose for patients receiving chlorthalidone.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetyldigoxin

Albiglutide

Albuterol

Alogliptin

Amtolmetin Guacil

Arsenic Trioxide

Aspirin

Bepridil

Bufexamac

Chlorpropamide

Choline Salicylate

Clonixin

Codeine

Dapagliflozin

Deslanoside

Desmopressin

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitalis

Digitoxin

Digoxin

Dipyrone

Dofetilide

Droperidol

Droxicam

Dulaglutide

Empagliflozin

Etodolac

Etofenamate

Etoricoxib

Exenatide

Felbinac

Fenoprofen

Fepradinol

Feprazone

Flecainide

Floctafenine

Flufenamic Acid

Flurbiprofen

Formoterol

Glimepiride

Glipizide

Glyburide

Ibuprofen

Indomethacin

Insulin

Insulin Aspart, Recombinant

Insulin Bovine

Insulin Degludec

Insulin Detemir

Insulin Glulisine

Ketanserin

Ketoprofen

Ketorolac

Levomethadyl

Linagliptin

Liraglutide

Lithium

Lixisenatide

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Methotrexate

Metildigoxin

Miglitol

Morniflumate

Nabumetone

Naproxen

Nateglinide

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Oxaprozin

Oxyphenbutazone

Parecoxib

Phenylbutazone

Piketoprofen

Pioglitazone

Piroxicam

Pramlintide

Proglumetacin

Propyphenazone

Proquazone

Repaglinide

Rofecoxib

Rosiglitazone

Salicylic Acid

Salsalate

Saxagliptin

Sitagliptin

Sodium Salicylate

Sotalol

Sulindac

Tapentadol

Tenoxicam

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolfenamic Acid

Tolmetin

Valdecoxib

Vildagliptin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aminolevulinic Acid

Gossypol

Licorice

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

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How to use Thalitone

Take this medicine exactly as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To help you remember to take your medicine, try to get into the habit of taking it at the same time each day.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium or potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

This medicine is usually taken in the morning with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For fluid retention (edema):

Adults—At first, 50 to 100 milligrams (mg) once a day, or 100 mg once every other day. Your doctor may adjust your dose if needed.

Children—Use and dose must be determined by your doctor.

For high blood pressure:

Adults—

Chlorthalidone: At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed.

Thalitone®: At first, 15 mg once a day. After 2 weeks, your dose may be increased to 25 mg per day as needed.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

This medicine may cause you to lose more potassium from your body than normal (hypokalemia). Tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea, and drink fluids to prevent getting dehydrated. Check with your doctor right away if you have dry mouth, increased thirst, muscle cramps, or nausea or vomiting.

This medicine may cause some people to become dizzy. Do not drive, use machines, or do anything else that could be dangerous if you are dizzy.

Drinking alcoholic beverages may also make the dizziness worse. While you are taking this medicine, be careful to limit the amount of alcohol you drink.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

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