Thiothixene

Generic name: Thiothixene
Brand names: Navane
Dosage form: oral capsule (1 mg; 10 mg; 2 mg; 5 mg)
Drug class: Thioxanthenes

Usage of Thiothixene

Thiothixene is an antipsychotic medicine that is used to treat schizophrenia.

Thiothixene may also be used for purposes not listed in this medication guide.

Thiothixene side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of thiothixene can cause a serious movement disorder that may not be reversible. The longer you use thiothixene, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Thiothixene may cause serious side effects. Call your doctor at once if you have:

uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

stiffness in your neck, tightness in your throat, trouble breathing or swallowing;

seizure (convulsions);

a light-headed feeling, like you might pass out;

severe constipation;

low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or

severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects of thiothixene may include:

dry mouth;

blurred vision;

nausea, vomiting, diarrhea, constipation;

fast heartbeats, feeling restless;

breast swelling or discharge;

changes in weight or appetite; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Thiothixene

You should not use thiothixene if you are allergic to it, or if you have:

a blood cell disorder such as anemia, low white blood cell counts, or low platelets; or

drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

Thiothixene may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

epilepsy or other seizure disorder;

heart disease;

low white blood cell (WBC) counts;

breast cancer; or

alcoholism.

Tell your doctor if you are pregnant or if you become pregnant. Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.

It may not be safe to breastfeed while using thiothixene. Ask your doctor about any risk.

Thiothixene is not approved for use by anyone younger than 12 years old.

Relate drugs

How to use Thiothixene

Usual Adult Dose for Schizophrenia:

Mild Conditions: -Initial dose: 2 mg orally 3 times a day-Maintenance dose: 15 mg orally per day Severe Conditions:-Initial dose: 5 mg orally 2 times a day-Maintenance dose: 20 to 30 mg orally per day -Maximum dose: 60 mg orally per dayComments:-Dosing should be individually adjusted depending on the chronicity and severity of symptoms.-In general, small doses should be used initially and gradually increased to the optimal effective level based on patient response.-Some patients have been successfully maintained on once-a-day therapy.Use: Schizophrenia

Usual Pediatric Dose for Schizophrenia:

Age 12 years and older:Mild Conditions: -Initial dose: 2 mg orally 3 times a day-Maintenance dose: 15 mg orally per day Severe Conditions:-Initial dose: 5 mg orally 2 times a day-Maintenance dose: 20 to 30 mg orally per day -Maximum dose: 60 mg orally per dayComments:-Dosing should be individually adjusted depending on the chronicity and severity of symptoms.-In general, small doses should be used initially and gradually increased to the optimal effective level based on patient response.-Some patients have been successfully maintained on once-a-day therapy.Use: Schizophrenia

Warnings

You should not use thiothixene if you have a blood cell disorder, or if you have drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

Thiothixene is not approved for use in older adults with dementia-related psychosis.

What other drugs will affect Thiothixene

Taking thiothixene with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect thiothixene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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