Tisseel

Generic name: Fibrin Sealant Topical
Drug class: Miscellaneous coagulation modifiers

Usage of Tisseel

Fibrin sealant is made of two substances from human plasma that work together to help your blood clot.

Tisseel is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. This medicine may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed.

Tisseel is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery.

Tisseel may also be used for purposes not listed in this medication guide.

Tisseel side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, warmth, redness, numbness, tingly feeling; nausea, vomiting, feeling light-headed, fast or slow heartbeats; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Fibrin sealant is sometimes applied with a spray device that uses gas pressure. High pressure may cause the release of air or gas under the skin tissues, where it can then travel throughout the body. This may be more likely when high pressure settings are improperly used by a healthcare provider during the spray application of fibrin sealant. Air or gas trapped within the body can cause serious or life-threatening effects. Talk with your doctor about this risk.

Tell your caregivers at once if you have:

  • chest pain, cough, trouble breathing, gasping for breath;
  • confusion, agitation, panic, extreme fear;
  • sudden numbness or weakness (especially on one side of the body);
  • sudden severe headache, slurred speech, problems with vision or balance;
  • blue-colored appearance of your skin or lips;
  • nausea, dizziness or spinning sensation;
  • a light-headed feeling, like you might pass out; or
  • redness, itching, irritation, or slow healing of the skin wound or treated area;

    • Common side effects of Tisseel may include:

  • itching; or
  • swelling or bruising.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Tisseel

    You should not be treated with Tisseel if you are allergic to cows or products made from cows.

    It is not known whether Tisseel will harm an unborn baby. Tell your doctor if you are pregnant.

    It is not known whether fibrin sealant topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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    How to use Tisseel

    Tisseel can be sprayed or dripped onto the affected skin or surgical area. Tisseel is applied by a healthcare professional in a surgical or clinical setting.

    Tisseel is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

    Some people develop symptoms of a viral infection after being treated with Tisseel. Call your doctor if you have flu-like symptoms such as fever, chills, drowsiness, or a runny nose. You may also have joint pain and a skin rash about 2 weeks after the start of your flu symptoms.

    Warnings

    You should not be treated with Tisseel if you are allergic to cows or products made from cows.

    What other drugs will affect Tisseel

    It is not likely that other drugs you take orally or inject will have an effect on topically applied fibrin sealant. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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