Tivozanib

Generic name: Tivozanib
Brand names: Fotivda
Dosage form: oral capsule (1340 mcg; 890 mcg)
Drug class: VEGF/VEGFR inhibitors

Usage of Tivozanib

Tivozanib is used to treat advanced kidney cancer in adults, after at least two other cancer treatments did not work or have stopped working.

Tivozanib may also be used for purposes not listed in this medication guide.

Tivozanib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tivozanib may cause serious side effects. Call your doctor at once if you have:

severe headache, confusion, dizziness;

a seizure;

chest pain, shortness of breath;

blurred vision, pounding in your neck or ears;

swelling in your lower legs, rapid weight gain;

any wound that will not heal;

easy bruising or bleeding (nosebleeds, bleeding gums);

signs of bleeding inside your body--weakness, dizziness; pink or brown urine; abnormal vaginal bleeding; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

signs of a blood clot--sudden numbness or weakness on one side of the body, chest pain, problems with vision or speech, pain or swelling in an arm or leg; or

kidney problems--swelling, puffy eyes, foamy urine.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of tivozanib may include:

nausea, vomiting, diarrhea, loss of appetite;

feeling weak or tired;

cough, hoarse voice;

mouth sores; or

abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Tivozanib

Tell your doctor if you have ever had:

heart problems;

high blood pressure;

a blood clot, heart attack, or stroke;

bleeding problems;

surgery, including oral surgery;

a wound that has not healed;

a thyroid disorder;

liver disease; or

an allergy to aspirin or yellow dye (tartrazine).

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using tivozanib should use effective birth control to prevent pregnancy. Tivozanib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using tivozanib.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Relate drugs

How to use Tivozanib

Usual Adult Dose for Renal Cell Carcinoma:

1.34 mg orally once a day for 21 days followed by 7 days off (28-day cycle) until disease progression or unacceptable toxicityUse: For adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following 2 or more prior systemic therapies

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Tivozanib

Other drugs may affect tivozanib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.