Tosymra

Generic name: Sumatriptan
Dosage form: nasal spray
Drug class: Antimigraine agents

Usage of Tosymra

Tosymra is a nasal spray medicine used to treat acute migraine headaches with or without aura in adults. It is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines. Tosymra is not used to prevent or decrease the number of migraines you have. Tosymra is not used to treat cluster headaches. It is not known if it is safe and effective in children under 18 years of age.

Tosymra is a serotonin (5-HT1B/1D) receptor agonist (triptan)

Tosymra side effects

Tosymra may cause serious side effects.

Also see “Important information"

These serious side effects include:

changes in color or sensation in your fingers and toes (Raynaud’s syndrome)

stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:

sudden or severe stomach pain o stomach pain after meals

weight loss

nausea or vomiting

constipation or diarrhea

bloody diarrhea

fever

problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:

cramping and pain in your legs or hips

feeling of heaviness or tightness in your leg muscles

burning or aching pain in your feet or toes while resting

numbness, tingling, or weakness in your legs

cold feeling or color changes in 1 or both legs or feet

medication overuse headaches. Some people who use too much migraine medicine, such as Tosymra, for 10 or more days each month may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with Tosymra.

serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using Tosymra, especially if this medicine is used with antidepressant medicines called SSRIs or SNRIs. Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:

mental changes such as seeing things that are not there (hallucinations), agitation, or coma

fast heartbeat

changes in blood pressure

high body temperature

tight muscles

trouble walking

increased blood pressure including a sudden severe increase (hypertensive crisis) even if you have no history of high blood pressure.

hives (itchy bumps); swelling of your tongue, mouth, or throat.

seizures. Seizures have happened in people taking Tosymra who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take Tosymra.

The most common side effects of Tosymra include:

tingling&

dizziness

feeling warm or hot

burning feeling feeling of heaviness

feeling of pressure flushing

feeling of tightness

numbness

application site (nasal) reactions

abnormal taste

throat irritation;

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Tosymra. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1- 800-FDA-1088.

Before taking Tosymra

Pregnancy or planning to become pregnant: Tell your doctor. It is not known if Tosymra can harm your unborn baby.

Breastfeeding or planning to breastfeed. Tosymra passes into your breast milk. It is not known if this can harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take Tosymra.

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How to use Tosymra

The recommended dose of Tosymra is 10 mg given as a single spray in one nostril.

The maximum cumulative dose that may be given in a 24-hour period is 30 mg, with doses of Tosymra separated by at least 1 hour. Tosymra may also be given at least 1 hour following a dose of another sumatriptan product.

Warnings

Tosymra can cause serious side effects, including:

Heart attack and other heart problems. Heart problems may lead to death.

Stop taking Tosymra and get emergency medical help right away if you have any of the following symptoms of a heart attack:

discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back

severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw

pain or discomfort in your arms, back, neck, jaw, or stomach

shortness of breath with or without chest discomfort

breaking out in a cold sweat, nausea or vomiting

feeling lightheaded

Tosymra is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

have high blood pressure

have high cholesterol levels

smoke

are overweight

have diabetes

have a family history of heart disease

What other drugs will affect Tosymra

Tosymra and certain other medicines can affect each other, causing serious side effects. Especially tell your healthcare provider if you take anti-depressant medicines called:

selective serotonin reuptake inhibitors (SSRIs)

serotonin norepinephrine reuptake inhibitors (SNRIs)

tricyclic antidepressants (TCAs)

monoamine oxidase inhibitors (MAOIs)

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.