Trandolapril and verapamil

Generic name: Trandolapril And Verapamil
Brand names: Tarka
Dosage form: oral tablet, extended release (1 mg-240 mg; 2 mg-180 mg; 2 mg-240 mg; 4 mg-240 mg)
Drug class: ACE inhibitors with calcium channel blocking agents

Usage of Trandolapril and verapamil

Trandolapril and verapamil is a combination medicine used in adults to treat high blood pressure (hypertension).

Lowering blood pressure may lower your risk of a stroke or heart attack.

Trandolapril and verapamil may also be used for purposes not listed in this medication guide.

Trandolapril and verapamil side effects

Get emergency medical help if you have signs of an allergic reaction: severe stomach pain, hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Trandolapril and verapamil may cause serious side effects. Call your doctor at once if you have:

chest pain, fast, slow, or uneven heart rate;

a light-headed feeling, like you might pass out;

heart problems--swelling, rapid weight gain, feeling short of breath;

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

fluid build-up in or around the lungs--pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats;

high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;

kidney problems--swelling, urinating less, feeling tired or short of breath; or

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects of trandolapril and verapamil may include:

cough;

nausea, constipation;

infections, flu symptoms;

headache, dizziness;

swelling;

low blood pressure; or

chest pain, back pain, joint pain, pain in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Trandolapril and verapamil

You should not use trandolapril and verapamil if you are allergic to it, or if you have:

"sick sinus syndrome" or "AV block" (unless you have a pacemaker);

very low blood pressure;

if your heart cannot pump blood properly;

an allergy to any other ACE inhibitor, such as Benazepril, Captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, or ramipril;

certain heart rhythm disorders (such as 'Afib' or atrial flutter, Wolff-Parkinson-White syndrome or Lown-Ganong-Levine syndrome); or

if you also use flibanserin (Addyi).

You may not be able to use trandolapril and verapamil if you have:

severe congestive heart failure.

Do not take trandolapril and verapamil within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not take trandolapril and verapamil with any medication that contains aliskiren (a blood pressure medicine).

Tell your doctor if you have ever had:

low blood pressure;

abnormal thickening of the heart muscle;

congestive heart failure;

a nerve-muscle disorder such as myasthenia gravis or muscular dystrophy;

low blood cell counts;

diabetes;

cirrhosis or other liver disease; or

kidney disease (or if you are on dialysis).

You may also need to avoid taking trandolapril and verapamil with aliskiren if you have kidney disease.

Stop using this medicine and tell your doctor right away if you become pregnant. Trandolapril and verapamil can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

Relate drugs

How to use Trandolapril and verapamil

Usual Adult Dose for Hypertension:

Initial dose should be based on the patient's requirements for each drug.Comments: Patients receiving trandolapril (up to 8 mg) and verapamil (up to 240 mg) in separate tablets may receive this drug once a day in equivalent dosages.

Warnings

Do not use if you are pregnant. Stop using trandolapril and verapamil and tell your doctor right away if you become pregnant.

You should not use this medicine if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), Wolff-Parkinson-White syndrome, or Lown-Ganong-Levine syndrome.

Tell your doctor about all your other medicines. Some drugs should not be used with trandolapril and verapamil.

What other drugs will affect Trandolapril and verapamil

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Trandolapril and verapamil can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, pain or arthritis (including Advil, Motrin, and Aleve).

If you also take disopyramide, avoid taking it within 48 hours before or 24 hours after you take trandolapril and verapamil.

Many drugs can affect trandolapril and verapamil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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