Tranexamic acid

Generic name: Tranexamic Acid (Cyklokapron)
Brand names: Cyklokapron
Dosage form: intravenous solution (10 mg/mL-NaCl 0.7%; 100 mg/mL)
Drug class: Miscellaneous coagulation modifiers

Usage of Tranexamic acid

Tranexamic acid prevents enzymes in the body from breaking down blood clots.

Cyklokapron is used to prevent bleeding in people with hemophilia who need to have a tooth pulled. This medication is usually given just before the dental procedure, and daily for up to 8 days afterward.

Tranexamic acid may also be used for purposes not listed in this medication guide.

Tranexamic acid side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Cyklokapron may cause serious side effects. Stop using Cyklokapron and call your doctor at once if you have:

problems with your vision (including color vision);

a light-headed feeling, like you might pass out;

a seizure;

painful or difficult urination, blood in your urine;

signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;

signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

signs of a blood clot in your leg--swelling, warmth, or redness in an arm or leg.

Common side effects include:

nausea, vomiting, diarrhea;

dizziness, feeling light-headed;

mild itching or rash; or

feeling unusually happy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Tranexamic acid

You should not use Cyklokapron if you are allergic to tranexamic acid, or if you have:

problems with the blood vessels in your eyes;

color blindness (only if you are receiving the injectable form of tranexamic acid); or

a history of stroke, blood clot, or bleeding in your brain.

Tell your doctor if you have ever had:

kidney disease;

a bladder or kidney infection; or

leukemia.

Tell your doctor if you are pregnant or breastfeeding.

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How to use Tranexamic acid

Usual Adult Dose for Bleeding:

Initial dose: 10 mg/kg intravenously, immediately before dental extraction Maintenance dose: 10 mg/kg intravenously three to four times dailyDuration of therapy: 2 to 8 daysComments: Infuse no more than 1 mL/minute to avoid hypotension.Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following a tooth extraction.

Usual Adult Dose for Menstrual Disorders:

Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruationDuration: Maximum of 5 daysUse: For the treatment of cyclic heavy menstrual bleeding

Usual Pediatric Dose for Bleeding:

Initial dose: 10 mg/kg intravenously, immediately before dental extraction Maintenance dose: 10 mg/kg intravenously three to four times dailyDuration of therapy: 2 to 8 daysComments: -The limited data suggest that dosing instructions for adults can be used for pediatric patients needing therapy for tooth extractions. -Infuse no more than 1 mL/minute to avoid hypotension.Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during tooth extractions.

Usual Pediatric Dose for Menstrual Disorders:

Post menarchal females: Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruationDuration: Maximum of 5 days Use: For the treatment of cyclic heavy menstrual bleeding in post-menarchal females

Warnings

You should not use Cyklokapron if you are color blind, if you have problems with the blood vessels in your eyes, or if you have ever had a stroke, blood clot, or bleeding in your brain.

What other drugs will affect Tranexamic acid

Tell your doctor about all your other medicines, especially:

any type of medication to treat a bleeding episode or a blood clot; or

factor IX complex (Bebulin, Bebulin VH, Profilnine, and others).

This list is not complete. Other drugs may affect Cyklokapron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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