Trazodone

Generic name: Trazodone
Dosage form: oral tablet (100 mg; 150 mg; 300 mg; 50 mg)
Drug class: Phenylpiperazine antidepressants

Usage of Trazodone

Trazodone is an antidepressant that belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). While trazodone is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the SSRIs.

Trazodone is used to treat major depressive disorder.

It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression.

Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain.

Trazodone side effects

Get emergency medical help if you have signs of an allergic reaction to trazodone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

slow heartbeats;

unusual thoughts or behavior;

easy bruising, unusual bleeding; or

low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common trazodone side effects may include:

drowsiness, dizziness, tiredness;

swelling;

weight loss;

blurred vision;

diarrhea, constipation; or

stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Trazodone

You should not use trazodone if you are allergic to it.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with trazodone could cause a serious condition called serotonin syndrome.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver or kidney disease;

heart disease, or a recent heart attack;

a bleeding or blood clotting disorder;

seizures or epilepsy;

narrow-angle glaucoma;

long QT syndrome;

drug addiction or suicidal thoughts; or

bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking trazodone during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop this medicine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Trazodone is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Trazodone

Usual Adult Dose for Depression:

Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days Maximum dose: -Inpatients: 600 mg/day -Outpatients: 400 mg/day Comments: -Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment. -Patients should be monitored for withdrawal symptoms when discontinuing therapy. -After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response. -If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary. -This drug should be taken shortly after a meal or light snack. Use: Treatment of major depressive disorder (MDD)

Warnings

You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, tranylcypromine and others.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children.

What other drugs will affect Trazodone

Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can interact with trazodone, especially:

any other antidepressants;

phenytoin;

St. John's wort;

tramadol;

a diuretic or "water pill";

medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;

a blood thinner - warfarin, Coumadin, Jantoven; or

migraine headache medicine - sumatriptan, Imitrex, Maxalt, Treximet, and others.

This list is not complete and many other drugs may interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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