Trelegy Ellipta

Generic name: Fluticasone, Umeclidinium, And Vilanterol
Drug class: Bronchodilator combinations

Usage of Trelegy Ellipta

Trelegy Ellipta is used to treat COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema, and is also used for asthma in adults as a maintenance treatment. Trelegy Ellipta is used daily to improve symptoms and prevent bronchospasm in adults with COPD, and for adults with asthma, it is used daily to prevent and control symptoms of asthma.

Trelegy Ellipta is an inhalation powder containing a combination of fluticasone, umeclidinium, and vilanterol.

Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Umeclidinium is an anticholinergic. Vilanterol is a long-acting bronchodilator. These medications work by relaxing muscles in the airways to improve breathing.

Trelegy Ellipta is not for use in treating an asthma attack or bronchospasm attack.

Vilanterol, when used alone, may increase the risk of death in people with asthma. However, this risk is not increased when vilanterol is used in a combination product with fluticasone and umeclidinium.

Trelegy Ellipta side effects

Common Trelegy Ellipta side effects may include:

cold or flu symptoms such as runny or stuffy nose, sore throat, cough, chest tightness;

a lung infection;

nausea, vomiting, constipation, diarrhea;

joint pain;

mouth sores, hoarse voice;

headache, back pain; or mouth pain, changes in your sense of taste.

Serious Trelegy Ellipta side effects

Get emergency medical help if you have signs of an allergic reaction to Trelegy Ellipta: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

tremors, nervousness, chest pain, fast or pounding heartbeats;

sores or white patches in your mouth and throat, pain when swallowing;

wheezing, choking, or other breathing problems after using this medicine;

painful or difficult urination;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

a lung infection - fever, chills, cough with mucus, feeling short of breath;

high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;

low potassium level - leg cramps, constipation, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle weakness or limp feeling; or

signs of a hormonal disorder - worsening tiredness or muscle weakness, feeling light-headed, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Trelegy Ellipta

You should not use Trelegy Ellipta if you are allergic to fluticasone, umeclidinium, vilanterol, or milk proteins.

Tell your doctor if you have ever had:

heart disease, high blood pressure;

a seizure;

a weak immune system;

any type of bacterial, fungal, or viral infection or an infection caused by parasites;

liver disease;

glaucoma, cataracts, or other vision problems;

diabetes (or ketoacidosis);

osteoporosis;

a thyroid disorder; or

an enlarged prostate, bladder obstruction, or urination problems.

If you have been using an oral steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.

It is not known whether Trelegy Ellipta will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using Trelegy Ellipta. Ask your doctor about any risks.

Trelegy Ellipta is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Trelegy Ellipta

Usual Adult Dose of Trelegy Ellipta for Chronic Obstructive Pulmonary Disease - Maintenance

Maintenance:1 inhalation (100 mcg-62.5 mcg-25 mcg or 200 mcg-62.5 mcg-25 mcg) orally once a day Maximum dose: 1 inhalation every 24 hours Comments: -More frequent administration or a greater number of inhalations than the recommended dose should not be used, as adverse effects are more likely to occur with higher doses. -Use with caution when transferring from systemically active corticosteroid therapy. -Patients requiring oral corticosteroids should be weaned slowly from systemic corticosteroid use after transferring to this drug. Use: -Long-term maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema -Reduce exacerbations of COPD in patients with a history of exacerbations.

Usual Adult Dose for Asthma - Maintenance

Maintenance: 1 inhalation (fluticasone/umeclidinium/vilanterol 100 mcg-62.5 mcg-25 mcg or 200 mcg-62.5 mcg-25 mcg) orally once a day Maximum dose: 1 inhalation (fluticasone/umeclidinium/vilanterol 200 mcg-62.5 mcg-25 mcg) every 24 hours Comments: -When choosing a starting dose, consider disease severity, previous asthma therapy (including inhaled corticosteroid use), current symptom control, and risk of future exacerbations. -Patients with inadequate response to fluticasone/umeclidinium/vilanterol 100 mcg-62.5 mcg-25 mcg may gain additional improvement with fluticasone/umeclidinium/vilanterol 200 mcg-62.5 mcg-25 mcg. -Consider reevaluation and other therapies if the response to fluticasone/umeclidinium/vilanterol 200 mcg-62.5 mcg-25 mcg is inadequate. -If asthma symptoms arise between doses, use an inhaled short-acting beta-2 agonist (e.g. albuterol) for immediate relief.

Warnings

Trelegy Ellipta is not a rescue medicine for asthma or bronchospasm attacks. It will not work fast enough to treat a bronchospasm attack. Use only fast-acting inhalation medicine for an attack.

Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Do not use Trelegy Ellipta:

to treat sudden, severe symptoms of COPD or asthma.

if you have a severe allergy to milk proteins. Ask your healthcare provider if you are not sure.

if you are allergic to fluticasone furoate, umeclidinium, vilanterol, or any of the ingredients in this medication.

What other drugs will affect Trelegy Ellipta

Tell your doctor about all your other medicines, especially:

atropine;

antifungal or antiviral medicine;

medicine to treat depression, anxiety, mood disorders, or mental illness;

cold or allergy medicine (Benadryl and others);

medicine to treat Parkinson's disease;

medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

medicine to treat overactive bladder; or

other long-acting bronchodilator asthma medication.

This list is not complete. Other drugs may interact with fluticasone, umeclidinium, and vilanterol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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