Tremfya

Generic name: Guselkumab
Drug class: Interleukin inhibitors

Usage of Tremfya

Tremfya is a monoclonal antibody that blocks a certain protein in the body that can cause inflammation and other immune responses.

Tremfya is used to treat moderate to severe plaque psoriasis in adults.

Tremfya is also used to treat active psoriatic arthritis in adults.

Tremfya side effects

Get emergency medical help if you have signs of an allergic reaction to Tremfya: hives, rash, itching; chest tightness, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Guselkumab can weaken (suppress) your immune system, and you may get an infection more easily.

Call your doctor at once if you have signs of infection, such as:

fever, chills, body aches, night sweats;

weight loss, feeling very tired;

cough (may contain blood or mucus), shortness of breath;

pain or burning when you urinate;

severe diarrhea or stomach cramps; or

skin redness, tingling, blisters, oozing, or sores that look different from psoriasis.

Common Tremfya side effects may include:

headache, joint pain;

diarrhea, stomach pain;

cold symptoms such as stuffy nose, sneezing, sore throat;

cough, feeling short of breath;

skin infections; or

pain, itching, swelling, redness, or bruising where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Tremfya

You should not use Tremfya if you are allergic to guselkumab or Polysorbate 80.

Tell your doctor if you have ever had tuberculosis, or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Before you start treatment with Tremfya, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

To make sure Tremfya is safe for you, tell your doctor if you have:

an active or chronic infection;

active tuberculosis infection that is not being treated; or

if you have recently received or are scheduled to receive any vaccine.

Make sure you are current on all vaccines before you start treatment with Tremfya.

It is not known whether guselkumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of guselkumab on the baby.

It is not known whether guselkumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breastfeeding.

Tremfya is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Tremfya

Usual Adult Dose for Psoriatic Arthritis:

100 mg suBCutaneously at Week 0, Week 4, and every 8 weeks thereafter Comments: -This drug may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (cDMARD) (e.g., methotrexate) Uses: -For the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy For the treatment of adults with active psoriatic arthritis

Usual Adult Dose for Plaque Psoriasis:

100 mg subcutaneously at Week 0, Week 4, and every 8 weeks thereafter Comments: -This drug may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (cDMARD) (e.g., methotrexate) Uses: -For the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy For the treatment of adults with active psoriatic arthritis

Warnings

Tremfya can weaken (suppress) your immune system, and you may get an infection more easily.

Call your doctor if you have signs of infection such as fever, sweats, chills, muscle aches, weight loss, severe diarrhea, stomach cramps, pain or burning when you urinate, cough (may contain blood or mucus), shortness of breath, or skin sores that look different from psoriasis.

What other drugs will affect Tremfya

Other drugs may interact with guselkumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.