Treprostinil

Generic name: Treprostinil (oral)
Dosage form: oral tablet, extended release (0.125 mg; 0.125 mg-0.25 mg; 0.125 mg-0.25 mg-1 mg; 0.25 mg; 1 mg; 2.5 mg; 5 mg)
Drug class: Agents for pulmonary hypertension

Usage of Treprostinil

Treprostinil is used in adults to treat high blood pressure in the arteries of the lungs also known as pulmonary arterial hypertension (PAH). treprostinil improves your ability to exercise and can help prevent your condition from getting worse.

Treprostinil may also be used for purposes not listed in this medication guide.

Treprostinil side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Treprostinil may cause serious side effects. Call your doctor at once if you have:

chest pain, trouble breathing, tiredness, pale skin, swelling in arms or legs; or

a light-headed feeling, like you might pass out.

Common side effects of treprostinil may include:

headache;

stomach pain;

jaw pain, pain in your arms or legs;

diarrhea, nausea, vomiting; or

flushing (sudden warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Treprostinil

You should not use treprostinil if you have severe liver disease.

Tell your doctor if you have or have ever had:

diverticulosis (an intestinal disorder); or

liver disease.

It is not known if treprostinil will harm an unborn baby. However, having high lung blood pressure during pregnancy may cause complications or medical problems in both mother and baby. The benefit of treating pulmonary hypertension may outweigh any risks to the baby.

Ask a doctor if it is safe to breastfeed while using treprostinil.

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How to use Treprostinil

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take with food.

Swallow the tablet whole and do not crush, chew, or break it. Do not use a cracked or broken tablet.

Treprostinil is usually taken 2 to 3 times per day. Follow your doctor's instructions. Your dose may change if you have side effects.

Use treprostinil regularly for the best results.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

You should not stop taking treprostinil suddenly. Your condition may get worse if you stop taking treprostinil. Follow your doctor's instructions about tapering your dose.

Part of a tablet shell may appear in your stool but this will not make the medicine less effective.

Store at room temperature away from moisture and heat.

Warnings

You should not use treprostinil if you have severe liver disease.

You should not stop taking treprostinil suddenly. Your condition may get worse if you stop taking treprostinil.

What other drugs will affect Treprostinil

Tell your doctor about all your other medicines, especially:

gemfibrozil; or

medicine that contains treprostinil--Remodulin, Tyvaso, or Tyvaso DPI.

This list is not complete. Other drugs may affect treprostinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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