Triamcinolone (Systemic)
Brand names: Kenalog
Drug class:
Antineoplastic Agents
Usage of Triamcinolone (Systemic)
Treatment of a wide variety of diseases and conditions principally for glucocorticoid effects as an anti-inflammatory and immunosuppressant agent and for its effects on blood and lymphatic systems in the palliative treatment of various diseases.
Usually inadequate alone for adrenocortical insufficiency because essentially devoid of mineralocorticoid activity.
Adrenocortical Insufficiency
Corticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency.
Because production of both mineralocorticoids and glucocorticoids is deficient in adrenocortical insufficiency, hydrocortisone or cortisone (in conjunction with liberal salt intake) usually is the corticosteroid of choice for replacement therapy.
If triamcinolone is used, must also administer a mineralocorticoid (fludrocortisone), particularly in infants.
Adrenogenital Syndrome
Lifelong glucocorticoid treatment of congenital adrenogenital syndrome.
In salt-losing forms, cortisone or hydrocortisone is preferred in conjunction with liberal salt intake; a mineralocorticoid may be necessary in conjunction through at least 5–7 years of age. A glucocorticoid, usually alone, is continued for long-term therapy after early childhood.
In hypertensive forms, a “short-acting” glucocorticoid with minimal mineralocorticoid activity (e.g., methylprednisolone, prednisone) is preferred; avoid long-acting glucocorticoids because of tendency toward overdosage and growth retardation.
Hypercalcemia
Treatment of hypercalcemia associated with malignancy.
Usually ameliorates hypercalcemia associated with bone involvement in multiple myeloma.
Treatment of hypercalcemia associated with sarcoidosis† [off-label].
Treatment of hypercalcemia associated with vitamin D intoxication† [off-label].
Not effective for hypercalcemia caused by hyperparathyroidism† [off-label].
Thyroiditis
Treatment of granulomatous (subacute, nonsuppurative) thyroiditis. Anti-inflammatory actions relieve fever, acute thyroid pain, and swelling.
Usually reserved for palliative therapy in severely ill patients unresponsive to salicylates and thyroid hormones.
May reduce orbital edema in endocrine exophthalmos (thyroid ophthalmopathy).
Rheumatic Disorders and Collagen Diseases
Short-term adjunctive treatment of acute episodes or exacerbations of rheumatic disorders (e.g., rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, acute gouty arthritis, synovitis of osteoarthritis, epicondylitis, acute nonspecific tenosynovitis, ankylosing spondylitis, acute and subacute bursitis, Reiter syndrome† [off-label] , rheumatic fever† [off-label] [especially with carditis] ) and collagen diseases (e.g., acute rheumatic carditis, systemic lupus erythematosus, polyarteritis nodosa† , vasculitis† ) refractory to more conservative measures.
Relieves inflammation and suppresses symptoms but not disease progression.
Rarely indicated as maintenance therapy.
Local injection (intra-articular or soft-tissue administration) can provide relief initially for articular manifestations of rheumatic disorders (e.g., rheumatoid arthritis) that involve only a few persistently inflamed joints or for inflammation of tendons or bursae; inflammation tends to recur and sometimes is more intense after drug cessation.
Primary treatment to control symptoms and prevent severe, often life-threatening complications in patients with polyarteritis nodosa†, relapsing polychondritis†, polymyalgia rheumatica†, or mixed connective tissue disease syndrome†. High dosage may be required for acute situations; after a response has been obtained, drug must often be continued for long periods at low dosage.
Dermatologic Diseases
Treatment of pemphigus and pemphigoid† , bullous dermatitis herpetiformis, severe erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, uncontrollable eczema† , cutaneous sarcoidosis† , mycosis fungoides, lichen planus, severe psoriasis, and severe seborrheic dermatitis.
For control of severe or incapacitating allergic conditions (e.g., contact dermatitis, atopic dermatitis) intractable to adequate trials of conventional treatment.
Chronic skin disorders seldom an indication for systemic glucocorticoids.
Intralesional or sublesional injections occasionally indicated for localized chronic skin disorders including keloids, psoriatic plaques, alopecia areata, discoid lupus erythematosus, necrobiosis lipoidica diabeticorum, granuloma annulare, or lichen simplex chronicus (neurodermatitis) unresponsive to topical therapy.
Rarely indicated systemically for alopecia (areata, totalis, or universalis). May stimulate hair growth, but hair loss returns when the drug is discontinued.
Allergic Conditions
For control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment and control of acute manifestations, including serum sickness, drug hypersensitivity reactions, and severe seasonal or perennial rhinitis.
Systemic therapy usually reserved for acute conditions and severe exacerbations.
For acute conditions, usually used in high dosage and with other therapies (e.g., antihistamines, sympathomimetics).
Reserve prolonged treatment of chronic allergic conditions for disabling conditions unresponsive to more conservative therapy and when risks of long-term glucocorticoid therapy are justified.
Ocular Disorders
To suppress a variety of allergic and nonpyogenic ocular inflammations.
To reduce scarring in ocular injuries†.
For the treatment of severe acute and chronic allergic and inflammatory processes involving the eye and adnexa (e.g., allergic conjunctivitis, keratitis, allergic corneal marginal ulcers, herpes zoster ophthalmicus, iritis and iridocyclitis, chorioretinitis, diffuse posterior uveitis and choroiditis, anterior segment inflammation, optic neuritis, sympathetic ophthalmia).
Sarcoidosis
Management of symptomatic sarcoidosis.
Systemic glucocorticoids are indicated for hypercalcemia; ocular, CNS, glandular, myocardial, or severe pulmonary involvement; or severe skin lesions unresponsive to intralesional injections of glucocorticoids.
Tuberculosis
Treatment of fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous therapy.
Hematologic Disorders
Management of acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura (ITP), secondary thrombocytopenia, erythroblastopenia, or congenital (erythroid) hypoplastic anemia.
High or even massive glucocorticoid dosages decrease bleeding tendencies and normalize blood counts; does not affect the course or duration of hematologic disorders.
Glucocorticoids may not affect or prevent renal complications in Henoch-Schoenlein purpura.
Insufficient evidence of effectiveness of glucocorticoids in aplastic anemia in children, but widely used.
GI Diseases
Short-term palliative therapy for acute exacerbations and systemic complications of ulcerative colitis, regional enteritis, and Crohn's disease†.
Do not use if a probability of impending perforation, abscess, or other pyogenic infection.
Rarely indicated for maintenance therapy in chronic GI diseases (e.g., ulcerative colitis) since does not prevent relapses and may produce severe adverse reactions with long-term administration.
Occasionally, low dosages, in conjunction with other supportive therapy, may be useful for disease unresponsive to the usual therapy indicated for chronic conditions.
Neoplastic Diseases
Alone or as a component of various chemotherapeutic regimens in the palliative treatment of neoplastic diseases of the lymphatic system (e.g., leukemias and lymphomas in adults and acute leukemias in children).
Treatment of breast cancer† ; glucocorticoids alone not as effective as other agents (e.g., cytotoxic agents, hormones, antiestrogens) and should be reserved for unresponsive disease.
Low Back Pain
Systemic corticosteroids have been used symptomatic relief of low back pain†, however current evidence suggests that corticosteroids do not seem to be effective for improving radicular or nonradicular low back pain.
Organ Transplants
In massive dosage, used concomitantly with other immunosuppressive drugs to prevent rejection of transplanted organs†.
Incidence of secondary infections is high with immunosuppressive drugs; limit to clinicians experienced in their use.
Nephrotic Syndrome and Lupus Nephritis
Treatment of idiopathic nephrotic syndrome without uremia.
Can induce diuresis and remission of proteinuria in nephrotic syndrome secondary to primary renal disease, especially when there is minimal renal histologic change.
Treatment of lupus nephritis.
Carpal Tunnel Syndrome
Local injection of glucocorticoids into the tissue near the carpal tunnel has been used in a limited number of patients to relieve symptoms (e.g., pain, edema, sensory deficit) of carpal tunnel syndrome†.
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How to use Triamcinolone (Systemic)
General
Alternate-Day Therapy
Discontinuance of Therapy
Administration
Administer by IM injection. Not for IV injection.
Administer for local effect by intra-articular, intrabursal, intrasynovial, intralesional (intradermal), sublesional, or soft-tissue injection.
Kenalog-10 indicated for intra-articular or intralesional use only; not for IV, IM, intraocular, epidural or intrathecal use.
Kenalog-40 and Kenalog-80 indicated for IM or intra-articular use only; not for IV, intradermal, intraocular, epidural, or intrathecal use.
Generally reserve IM therapy for patients who are not able to take oral therapy.
IM Administration
Triamcinolone AcetonideAdminister 40-mg/mL and 80-mg/mL sterile suspension by deep IM injection into gluteal muscle. The 10-mg/mL sterile suspension is not suitable for IM administration.
Shake vial before use to insure uniform suspension. For adults, a minimum needle length of 1.5 inches recommended; a longer needle may be required in obese patients. Use alternate sites for subsequent injections.
Because it is slowly absorbed, IM administration is not indicated when an immediate effect or short duration is required.
Do not administer IM for conditions prone to bleeding (e.g., ITP).
Intra-articular, Intrabursal, Intrasynovial, Intralesional, or Soft-tissue Administration
For treatment of joints, consult standard textbooks for administration techniques.
Triamcinolone AcetonideAdminister by intra-articular, intrabursal, intrasynovial, soft-tissue, intralesional, or sublesional injection.
Shake vial before use to insure uniform suspension.
For intralesional (or sublesional) injection, use the 10-mg/mL sterile suspension; the 40 mg/mL and 80 mg/mL sterile suspension is not intended for intralesional (intradermal) use.
Use a tuberculin syringe to facilitate intralesional or sublesional dosage measurement. May inject multiple sites if they are ≥1 cm apart.
For intra-articular, intrabursal, intrasynovial, or soft-tissue injection, may use either the 10, 40, or 80-mg/mL sterile suspension. A local anesthetic (e.g., procaine hydrochloride) may be infiltrated into soft tissue surrounding the joint and/or injected into the joint before administration of triamcinolone acetonide.
Dosage
Available as triamcinolone acetonide; dosage expressed in terms of the salt.
After a satisfactory response is obtained, decrease dosage in small decrements to the lowest level that maintains an adequate clinical response, and discontinue the drug as soon as possible.
Monitor patients continually for signs that indicate dosage adjustment is necessary, such as remissions or exacerbations of the disease and stress (surgery, infection, trauma).
High dosages may be required for acute situations of certain rheumatic disorders and collagen diseases; after a response has been obtained, drug often must be continued for long periods at low dosage.
High or massive dosages may be required in the treatment of pemphigus, exfoliative dermatitis, bullous dermatitis herpetiformis, severe erythema multiforme, or mycosis fungoides. Early initiation of systemic glucocorticoid therapy may be life-saving in pemphigus vulgaris. Reduce dosage gradually to the lowest effective level, but discontinuance may not be possible.
Pediatric Patients
Base pediatric dosage on severity of the disease and patient response rather than on strict adherence to dosage indicated by age, body weight, or body surface area.
Usual Dosage IMIn pediatric patients, the initial dose of triamcinolone may vary depending on the specific condition being treated. The range of initial doses is 0.11 mg/kg daily to 1.6 mg/kg daily in 3 or 4 divided doses (3.2 mg/m2 bsa/day to 48 mg/m2 bsa/day).
Adults
Usual Dosage IMTriamcinolone acetonide: Usually, 60 mg initially (using the 40-mg/mL or 80-mg/mL sterile suspension). May administer additional doses of 20–100 mg when signs and symptoms recur. Manufacturer states dosage is usually adjusted within the range of 40–80 mg depending on patient response. Some clinicians recommend administration at 6-week intervals, if possible, to minimize HPA suppression. Some patients may be well controlled with doses ≤20 mg.
Intra-articular, Intrabursal, Intrasynovial, or Soft-tissue InjectionDosage varies depending on location, size, and degree of inflammation.
Triamcinolone acetonide: Initially, 5–15 mg for large joints; 2.5–5 mg for small joints. Symptom relief generally occurs with dosages ≤40 mg for large joints and ≤10 mg for small joints. For soft-tissue injection in treatment of tendon sheath inflammation, 2.5–10 mg. Repeat when signs and symptoms recur.
Intra-articular or Soft-tissue InjectionDosage varies depending on location, size, and degree of inflammation.
Intralesional or Sublesional InjectionDosage varies depending on location, size, and degree of inflammation.
May inject intralesionally into multiple sites if ≥1 cm apart, but do not exceed total dosage of 30 mg at any one time.
Warnings
Contraindications
Warnings/Precautions
Warnings
Nervous System EffectsSerious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. May precipitate mental disturbances ranging from euphoria, insomnia, mood swings, depression and anxiety, and personality changes to frank psychoses. Use may aggravate emotional instability or psychotic tendencies.
Use with caution in patients with seizure disorders and patients with myasthenia gravis receiving anticholinesterase therapy.
Serious, potentially permanent, and sometimes fatal adverse neurologic events (e.g., spinal cord infarction, paraplegia, quadriplegia, cortical blindness, stroke, seizures, nerve injury, brain edema) reported rarely, often within minutes to 48 hours following epidural glucocorticoid injection given either with or without fluoroscopic guidance.
FDA states efficacy and safety of epidural glucocorticoid administration not established; not FDA-labeled for this use.
Adrenocortical InsufficiencyWhen given in supraphysiologic doses for prolonged periods, glucocorticoids may cause decreased secretion of endogenous corticosteroids by suppressing pituitary release of corticotropin (secondary adrenocortical insufficiency).
The degree and duration of adrenocortical insufficiency is highly variable among patients and depends on the dose, frequency and time of administration, and duration of glucocorticoid therapy.
Acute adrenal insufficiency (even death) may occur if the drugs are withdrawn abruptly or if patients are transferred from systemic glucocorticoid therapy to local (e.g., inhalation) therapy.
Withdraw triamcinolone very gradually following long-term therapy with pharmacologic dosages. (See Discontinuance of Therapy under Dosage and Administration.)
Adrenal suppression may persist up to 12 months in patients who receive large dosages for prolonged periods.
Until recovery occurs, signs and symptoms of adrenal insufficiency may develop if subjected to stress (e.g., surgery, trauma, infection) and replacement therapy may be required. Since mineralocorticoid secretion may be impaired, sodium chloride and/or a mineralocorticoid should also be administered.
If the disease flares up during withdrawal, dosage may need to be increased and followed by a more gradual withdrawal.
ImmunosuppressionIncreased susceptibility to infections secondary to glucocorticoid-induced immunosuppression. Certain infections (e.g., varicella [chickenpox], measles) can have a more serious or even fatal outcome in such patients. (See Increased Susceptibility to Infection under Warnings.)
Administration of live virus vaccines, including smallpox, is contraindicated in patients receiving immunosuppressive dosages of glucocorticoids.
Increased Susceptibility to InfectionCorticosteroids increase susceptibility to and mask symptoms of infection.
Infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic infections in any organ system, may be associated with glucocorticoids alone or in combination with other immunosuppressive agents; reactivation of latent infections may occur.
Infections may be mild, but they can be severe or fatal, and localized infections may disseminate.
Do not use, except in life-threatening situations, in patients with viral infections or bacterial infections not controlled by anti-infectives.
Some infections (e.g., varicella [chickenpox], measles) can have a more serious or even fatal outcome, particularly in children.
Children and any adult who are not likely to have been exposed to varicella or measles should avoid exposure to these infections while receiving glucocorticoids.
If exposure to varicella or measles occurs in susceptible patients, treat appropriately (e.g., VZIG, IG, acyclovir).
Use with great care in patients with known or suspected Strongyloides (threadworm) infection. Immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.
Not effective and can have detrimental effects in the management of cerebral malaria.
Can reactivate tuberculosis. Include chemoprophylaxis in patients with a history of active tuberculosis undergoing prolonged glucocorticoid therapy. Observe closely for evidence of reactivation.
Musculoskeletal EffectsMuscle wasting, muscle pain or weakness, delayed wound healing, and atrophy of the protein matrix of the bone resulting in osteoporosis, vertebral compression fractures, aseptic necrosis of femoral or humeral heads, or pathologic fractures of long bones are manifestations of protein catabolism that may occur during prolonged therapy with glucocorticoids. These adverse effects may be especially serious in geriatric or debilitated patients. A high-protein diet may help to prevent adverse effects associated with protein catabolism.
An acute, generalized myopathy can occur with the use of high doses of glucocorticoids, particularly in patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) or in patients receiving concomitant therapy with neuromuscular blocking agents (e.g., pancuronium).
Osteoporosis and related fractures are one of the most serious adverse effects of long-term glucocorticoid therapy. The American College of Rheumatology (ACR) has published guidelines on prevention and treatment of glucocorticoid-induced osteoporosis. Recommendations are made according to a patient's risk of fracture.
Ocular EffectsProlonged use may result in posterior suBCapsular and nuclear cataracts (particularly in children), exophthalmos, and/or increased IOP which may result in glaucoma or may occasionally damage the optic nerve.
Do not use in patients with active ocular herpes simplex infections for fear of corneal perforation.
Transient blindness, amblyopia, acute retinal necrosis syndrome, intraocular hemorrhage, and cortical blindness have occurred following epidural glucocorticoid injection.
Endocrine and Metabolic EffectsAdministration over a prolonged period may produce various endocrine disorders including hypercorticism (cushingoid state) and amenorrhea or other menstrual difficulties.
May decrease glucose tolerance, produce hyperglycemia, and aggravate or precipitate diabetes mellitus, especially in patients predisposed to diabetes mellitus. If glucocorticoid therapy is required in patients with diabetes mellitus, changes in insulin or oral antidiabetic agent dosage or diet may be necessary.
Exaggerated glucocorticoid response in patients with hypothyroidism.
Cardiovascular EffectsPossible association between use of glucocorticoids and left ventricular free-wall rupture; use with extreme caution in patients with recent MI.
Use with caution in patients with CHF or hypertension.
Sensitivity Reactions
Some commercially available injections of triamcinolone contain Benzyl Alcohol as a preservative and are not for use in neonates. Administration of injections preserved with benzyl alcohol has been associated with toxicity in neonates (gasping syndrome).
Anaphylaxis reported rarely in patients receiving corticosteroid therapy. Cases of serious anaphylaxis, including death, reported in individuals receiving triamcinolone acetonide injection, regardless of route of administration. Take appropriate precautionary measures prior to administration, especially in patients with a history of allergy to any drug.
General Precautions
MonitoringPrior to initiation of long-term glucocorticoid therapy, perform baseline ECGs, BP, chest and spinal radiographs, glucose tolerance tests, and evaluations of HPA-axis function in all patients.
Perform upper GI radiographs in patients predisposed to GI disorders, including those with known or suspected peptic ulcer disease or appreciable dyspepsia.
GU EffectsIncreased or decreased motility and number of sperm in some men.
GI EffectsCorticosteroids should be used with caution in patients with diverticulitis, nonspecific ulcerative colitis (if there is a probability of impending perforation, abscess, or other pyogenic infection), or those with recent intestinal anastomoses.
Use with caution in patients with active or latent peptic ulcer. Manifestations of peritoneal irritation following GI perforation may be minimal or absent in patients receiving corticosteroids. Suggest concurrent administration of antacids between meals to prevent peptic ulcer formation in patients receiving high dosages of corticosteroids.
Hematologic EffectsCortisone reported rarely to increase blood coagulability and to precipitate intravascular thrombosis, thromboembolism, and thrombophlebitis; use corticosteroids with caution in patients with thromboembolic disorders.
Specific Populations
PregnancyCorticosteroids have been shown to be teratogenic in many species when administered in clinical doses. No adequate and well-controlled studies in pregnant women. Use during pregnancy only potential benefit justifies potential risk to fetus.
LactationDistributed into milk. Caution if used in nursing women.
Pediatric UseEfficacy and safety of corticosteroids in pediatric patients are based on the well-established course of effect of corticosteroids. Adverse effects of corticosteroids in pediatric patients are similar to those in adults.
Published studies provide evidence of efficacy and safety in pediatric patients for treatment of nephrotic syndrome (>2 years of age), and aggressive lymphomas and leukemias (>1 month of age). Other indications for pediatric use of corticosteroids (e.g., severe asthma) are based on adequate and well-controlled trials conducted in adults.
Carefully observe pediatric patients with frequent measurements of BP, weight, height, intraocular pressure, and clinical evaluation for infection, psychosocial disturbances, thromboembolism, peptic ulcers, cataracts, and osteoporosis. Pediatric patients who are treated with corticosteroids by any route, including systemically administered corticosteroids, may experience a decrease in growth velocity.
Geriatric UseWith prolonged therapy, muscle wasting, muscle pain or weakness, delayed wound healing, and atrophy of the protein matrix of the bone resulting in osteoporosis, vertebral compression fractures, aseptic necrosis of femoral or humeral heads, or pathologic fractures of long bones may occur. May be especially serious in geriatric or debilitated patients. (See Musculoskeletal Effects under Cautions.)
Hepatic ImpairmentExaggerated glucocorticoid response in patients with cirrhosis.
Renal ImpairmentUse with caution in patients with renal insufficiency.
Common Adverse Effects
Associated with long-term therapy: bone loss, cataracts, indigestion, muscle weakness, back pain, bruising, oral candidiasis.
What other drugs will affect Triamcinolone (Systemic)
Metabolized by CYP3A4.
Drugs Affecting Hepatic Microsomal Enzymes
Inhibitors of CYP3A4: potential pharmacokinetic interaction (increased plasma triamcinolone concentrations).
Inducers of CYP3A4: potential pharmacokinetic interaction (decreased plasma triamcinolone concentrations).
Specific Drugs and Laboratory Tests
Drug or Test
Interaction
Comments
Amphotericin B
Enhanced potassium-wasting effects of glucocorticoids
Monitor for development of hypokalemia
Antibiotics, macrolide
Increased plasma concentrations of triamcinolone
May require a decrease in dosage of triamcinolone
Anticoagulants, oral
Potential altered anticoagulant effects
Monitor coagulation indices
Possible increased triamcinolone metabolism
Diuretics, potassium-depleting
Possible enhanced potassium-wasting effects of glucocorticoids
Monitor for development of hypokalemia
Ketoconazole
Potential decreased clearance and increased risk of adverse effects of triamcinolone
Decreased triamcinolone dosage may be necessary
NSAIAs
Possible increased risk of GI ulceration
Possible decreased serum salicylate concentrations. When corticosteroids are discontinued, serum salicylate concentration may increase possibly resulting in salicylate intoxication
Use concurrently with caution
Observe patients receiving both drugs closely for adverse effects of either drug
May be necessary to increase salicylate dosage when corticosteroids are administered concurrently or decrease salicylate dosage when corticosteroids are discontinued
Phenytoin
Possible increased triamcinolone metabolism
Increased triamcinolone dosage may be necessary
Rifampin
Possible increased triamcinolone metabolism
Increased triamcinolone dosage may be necessary
Vaccines and toxoids
May cause a diminished response to toxoids and live or inactivated vaccines
May potentiate replication of some organisms contained in live, attenuated vaccines
Can aggravate neurologic reactions to some vaccines (supraphysiologic dosages)
Generally, defer routine administration of vaccines or toxoids until corticosteroid therapy is discontinued
May need serologic testing to ensure adequate antibody response for immunization. Additional doses of the vaccine or toxoid may be necessary
May undertake immunization procedures in patients receiving nonimmunosuppressive doses of glucocorticoids or in patients receiving glucocorticoids as replacement therapy (e.g., Addison’s disease)
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