Trijardy XR
Generic name: Empagliflozin, Linagliptin, And Metformin
Dosage form: oral tablet, extended release (10 mg-5 mg-1000 mg; 12.5 mg-2.5 mg-1000 mg; 25 mg-5 mg-1000 mg; 5 mg-2.5 mg-1000 mg)
Drug class:
Antidiabetic combinations
Usage of Trijardy XR
Trijardy XR tablets contains a comination of empagliflozin, linagliptin, and metformin. Empagliflozin, linagliptin, and metformin are all oral diabetes medicines that help control blood sugar levels.
Trijardy XR is a prescription medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Trijardy XR is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.
Trijardy XR is not for treating type 1 diabetes.
Trijardy XR side effects
Get emergency medical help if you have signs of an allergic reaction to Trijardy XR: hives, itching, flaking or peeling skin; trouble swallowing, difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical attention right away if you have signs of a serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.
Stop taking Trijardy XR and call your doctor at once if you have:
Common Trijardy XR side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Trijardy XR
You should not use Trijardy XR if you are allergic to empagliflozin, linagliptin, or metformin, or if you have:
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Trijardy XR. Be sure your caregivers know ahead of time that you are using Trijardy XR.
To make sure Trijardy XR is safe for you, tell your doctor if you have ever had:
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk.
Follow your doctor's instructions about using Trijardy XR if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.
You should not use Trijardy XR during the second or third trimester of pregnancy.
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
Do not breastfeed while you are taking Trijardy XR.
Trijardy XR is not approved for use by anyone younger than 18 years old.
Relate drugs
- Actoplus Met
- Actoplus Met XR
- Alogliptin and metformin
- Alogliptin and pioglitazone
- Avandamet
- Avandaryl
- Canagliflozin and metformin
- Dapagliflozin and metformin
- Dapagliflozin and saxagliptin
- Duetact
- Empagliflozin and linagliptin
- Empagliflozin and metformin
- Empagliflozin, linagliptin, and metformin
- Ertugliflozin and metformin
- Ertugliflozin and sitagliptin
- Glimepiride and pioglitazone
- Glipizide and metformin
- Glucovance
- Glyburide and metformin
- Glyxambi
- Insulin degludec and liraglutide
- Insulin glargine and lixisenatide
- Invokamet
- Invokamet XR
- Janumet
- Janumet XR
- Jentadueto
- Jentadueto XR
- Kazano
- Kombiglyze XR
- Linagliptin and metformin
- Metaglip
- Metformin and pioglitazone
- Metformin and saxagliptin
- Metformin and sitagliptin
- Oseni
- Pioglitazone and glimepiride
- Pioglitazone and metformin
- PrandiMet
- Qtern
- Repaglinide and metformin
- Rosiglitazone and glimepiride
- Rosiglitazone and metformin
- Saxagliptin and dapagliflozin
- Saxagliptin and metformin
- Segluromet
- Sitagliptin and metformin
- Soliqua
- Soliqua 100/33
- Steglujan
- Synjardy
- Synjardy XR
- Trijardy XR
- Xigduo XR
- Xultophy
How to use Trijardy XR
Usual Adult Dose of Trijardy XR for Diabetes Type 2:
Individualize initial dose based on the patient's current regimen: -For patients on metformin, with or without linagliptin: Initiate with a similar metformin dose plus empagliflozin 10 mg and linagliptin 5 mg orally once a day -For patients on metformin and any regimen containing empagliflozin, with or without linagliptin: Initiate with a similar dose of metformin, the same empagliflozin dose, and linagliptin 5 mg orally once a day Monitor effectiveness and tolerability and adjust dose as appropriate not to exceed maximum doses -Maximum doses: Empagliflozin 25 mg/day; Linagliptin 5 mg/day; Metformin 2000 mg/day Comments: -When used in combination with insulin or an insulin secretagogue, a lower dose of insulin or insulin secretagogue should be considered to reduce the risk of hypoglycemia. -Correct volume depletion prior to beginning therapy. -Trijardy XR is not recommended in patients with type 1 diabetes mellitus; it may increase the risk of ketoacidosis in these patients. -This drug has not been studied in patients with a history of pancreatitis and therefore it is unknown if patients with a history of pancreatitis are at an increased risk for developing pancreatitis while using this drug. Uses: -As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. -Empagliflozin is indicated to reduce the risk of cardiovascular (CV) death in adults with type 2 diabetes mellitus and established CV disease.
Warnings
You should not use Trijardy XR if you have severe kidney disease (or if you are on dialysis) or diabetic ketoacidosis, or if you have ever had a severe allergic reaction to metformin, empagliflozin or linagliptin.
Call your doctor at once if you have signs of a serious side effect, such as severe pain in your upper stomach spreading to your back, vomiting, fast heart rate, dizziness, feeling very thirsty or hot, decreased urination, heavy sweating, or hot and dry skin.
Tell your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
In rare cases, Trijardy XR can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.
What other drugs will affect Trijardy XR
Other drugs may increase or decrease the effects of Trijardy XR on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may interact with empagliflozin, linagliptin, and metformin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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