Tukysa
Generic name: Tucatinib
Drug class:
HER2 inhibitors
Usage of Tukysa
Tukysa inhibits HER2, a gene that can play a role in the development of breast cancer and colorectal cancer.
Tukysa is used together with other medicines (trastuzumab and Capecitabine) to treat HER2-positive breast cancer. This combination chemotherapy is used when the cancer has spread to other parts of the body or cannot be removed with surgery.
Tukysa is also used together with trastuzumab to treat RAS wild-type HER2-positive colorectal cancer that has spread to other parts of the body or cannot be removed by surgery.
Tukysa is usually given after other treatments have failed.
Tukysa side effects
Get emergency medical help if you have signs of an allergic reaction to Tukysa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Tukysa side effects when used in combination with trastuzumab and capecitabine in adults with HER2-positive breast cancer include:
Common Tukysa side effects when used in combination with trastuzumab in adults with RAS wild-type HER2- positive colorectal cancer include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Tukysa
Both men and women using Tukysa should use effective birth control to prevent pregnancy. Tucatinib can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Tukysa.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because tucatinib can harm an unborn baby.
Do not breastfeed while using Tukysa, and for at least 1 week after your last dose.
You may need to prevent pregnancy or avoid breastfeeding for longer periods of time after you stop using capecitabine or trastuzumab. Read all medication guides you receive. Follow directions about pregnancy or breastfeeding after you stop combination chemotherapy.
Tell your doctor if you have ever had liver disease.
Relate drugs
- Ado-trastuzumab emtansine
- Enhertu
- Fam-trastuzumab deruxtecan
- Fam-trastuzumab deruxtecan-nxki
- Herceptin
- Herceptin Hylecta
- Herzuma
- Herzuma (Trastuzumab Intravenous)
- Herzuma (Trastuzumab-pkrb Intravenous)
- Hyaluronidase and trastuzumab
- Hyaluronidase, pertuzumab, and trastuzumab
- Kadcyla
- Margenza
- Margetuximab
- Margetuximab-cmkb
- Ogivri
- Ogivri (Trastuzumab Intravenous)
- Ogivri (Trastuzumab-dkst Intravenous)
- Ontruzant
- Ontruzant (Trastuzumab Intravenous)
- Ontruzant (Trastuzumab-dttb Intravenous)
- Perjeta
- Pertuzumab
- Pertuzumab, trastuzumab, and hyaluronidase-zzxf
- Phesgo
- Trastuzumab
- Trastuzumab and hyaluronidase-oysk
- Trastuzumab-anns
- Trastuzumab-dkst
- Trastuzumab-dttb
- Trastuzumab-pkrb
- Trazimera
- Tucatinib
- Tukysa
How to use Tukysa
Usual Adult Dose for Breast Cancer:
300 mg orally 2 times a day in combination with trastuzumab and capecitabine until disease progression or unacceptable toxicity Comments: -When given in combination with this drug, the recommended dose of capecitabine is 1000 mg/m2 orally 2 times daily taken within 30 minutes after a meal. Use: in combination with trastuzumab and capecitabine, is indicated for treatment of adult patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting
Usual Adult Dose for Colorectal Cancer:
300 mg orally 2 times a day combination with trastuzumab until disease progression or unacceptable toxicity
Use: in combination with trastuzumab for the treatment of adult patients with RAS wild-type HER2-positive unresectable or metastatic colorectal cancer that has progressed following treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.
Warnings
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tukysa may affect the way your other medicines work, and other medicines may affect the way Tukysa works.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions and allergies.
What other drugs will affect Tukysa
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with tucatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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