Turalio
Generic name: Pexidartinib
Drug class:
Multikinase inhibitors
Usage of Turalio
Turalio (pexidartinib) is used in adults to treat giant cell tumor of the tendon sheath (also called tenosynovial giant cell tumor, or pigmented villonodular synovitis) not likely to improve with surgery.
Turalio is available only from a certified pharmacy under a special program. You must be registered in the program and understand the risks and benefits of this medicine.
Turalio belongs to a class of medications called kinase inhibitors. Pexidartinib works by blocking the action of an abnormal protein that may help the tumor to shrink.
Turalio side effects
Get emergency medical help if you have signs of an allergic reaction to Turalio: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using Turalio and call your doctor at once if you have dark urine or jaundice (yellowing of the skin or eyes).
Tell your doctor if you have other symptoms of liver problems, such as:
Dosing may be delayed or permanently discontinued if you have certain side effects.
Common Turalio side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Turalio
To make sure Turalio is safe for you, tell your doctor if you have ever had:
Pexidartinib can harm an unborn baby if the mother or the father is using this medicine.
Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
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How to use Turalio
Usual Adult Dose for Giant Cell Tumor of Bone:
400 mg orally 2 times a day Use: For symptomatic (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery
Warnings
Turalio can cause severe or fatal effects on your liver. You will need frequent blood tests to check your liver function during treatment.
Stop using Turalio and call your doctor at once if you have dark urine or jaundice (yellowing of the skin or eyes).
Tell your doctor if you have other symptoms of liver problems, such as loss of appetite, stomach pain (upper right side), nausea, vomiting, tiredness, itching, or fever.
What other drugs will affect Turalio
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Pexidartinib can harm your liver, especially if you also use certain medicines for infections, tuberculosis, depression, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve).
Some medicines should be taken separately from your dose of this medicine:
You may not be able to take a proton pump inhibitor stomach acid reducer such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Prilosec, Protonix, and others.
This list is not complete and many other drugs may interact with pexidartinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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