Tykerb

Generic name: Lapatinib

Usage of Tykerb

Tykerb is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Tykerb is used to treat a certain type of hormone-related breast cancer that has progressed or spread after treatment with other cancer medicines.

In postmenopausal women, Tykerb is given in combination with a hormonal medicine called Femara (letrozole). In others, Tykerb is given together with a cancer medicine called Xeloda (Capecitabine).

Tykerb side effects

Get emergency medical help if you have signs of an allergic reaction to Tykerb: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tykerb can cause severe or fatal liver problems. Call your doctor right away if you have: upper stomach pain, itching, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Also call your doctor at once if you have:

a headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

severe or ongoing diarrhea;

new or worsening cough, wheezing, chest pain, feeling short of breath; or

severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Tykerb side effects may include:

indigestion, loss of appetite;

nausea, vomiting, diarrhea;

rash, itching, dry skin;

pain or redness on the palms of your hands or the soles of your feet;

problems with your fingernails or toenails;

feeling weak or tired;

nosebleeds, mouth sores;

thinning hair; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Tykerb

You should not use Tykerb if you are allergic to lapatinib.

To make sure Tykerb is safe for you, tell your doctor if you have:

heart disease;

liver disease (lapatinib can cause severe or fatal liver problems);

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

a personal or family history of long QT syndrome.

Do not use Tykerb if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Tell your doctor right away if you become pregnant.

It is not known whether lapatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking this medicine.

How to use Tykerb

Usual Adult Dose for Breast Cancer:

-HER2-POSITIVE METASTATIC BREAST CANCER (in combination with Xeloda): 1250 mg orally once a day on Days 1 to 21 continuously in repeating 21-day cycles until disease progression or unacceptable toxicity. -HORMONE RECEPTOR-POSITIVE, HER2-POSITIVE METASTATIC BREAST CANCER (in combination with Femara): 1500 mg orally once a day continuously. Comments: -Consult the manufacturer product information for Xeloda and Femara dosing recommendations. -HER2-positive metastatic breast cancer patients should have disease progression on trastuzumab prior to initiation of treatment with this drug in combination with Xeloda. Uses: -In combination with Xeloda for treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab. -In combination with Femara for treatment of postmenopausal women with hormone receptor-positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated.

Warnings

Do not use Tykerb if you are pregnant. It could harm the unborn baby.

Tykerb can cause severe or fatal liver problems.

Call your doctor at once if you have signs of liver problems: upper stomach pain, itching, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Before you take lapatinib, tell your doctor if you have heart disease, liver disease, an electrolyte imbalance (low potassium or magnesium), or a personal or family history of Long QT syndrome.

Take Tykerb on an empty stomach. Take this medication for the entire length of time prescribed by your doctor.

What other drugs will affect Tykerb

Tell your doctor about all your current medicines and any you start or stop using, especially:

an antacid or stomach acid reducer such as Prilosec or Nexium;

an antibiotic or antifungal medicine;

an antidepressant;

heart or blood pressure medication;

medicine to treat HIV or AIDS;

seizure medication; or

St. John's wort.

This list is not complete. Other drugs may interact with lapatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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