Ubrogepant

Generic name: Ubrogepant
Brand names: Ubrelvy
Dosage form: tablet
Drug class: CGRP inhibitors

Usage of Ubrogepant

Ubrogepant is a tablet used by adults to treat migraine headaches, it does not prevent migraines.

It was approved by the FDA in 2019 as studies showed that two hours after patients took ubrogepant, they HAD less pain and more freedom from their most bothersome migraine symptoms (eg. nausea, light sensitivity and sound sensitivity), when compared to other patients taking a placebo (dummy pill).

It is from the class of drugs called Calcitonin gene-related peptide (CGRP) receptor antagonists. CGRP is a protein in the nerve endings that is involved in pain and migraines. Ubrogepant blocks the CGRP protein from attaching to the nerve endings and so decreases the pain and migraine symptoms

Ubrogepant side effects

The most common side effects of ubrogepant are nausea and sleepiness.

These are not all of the possible side effects of this medicine. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ubrogepant

Pregnancy: Tell your doctor if you are pregnant or plan to become pregnant. It is not known if ubrogepant will harm your unborn baby.

Breastfeeding: Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if ubrogepant passes into your breast milk.

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How to use Ubrogepant

Take ubrogepant exactly as your healthcare provider tells you to take it.

You can take your ubrogepant tablet with or without food.

Most patients can take a second tablet 2 hours after the first tablet, as needed.

You should not take a second tablet within 24 hours if you consume grapefruit or grapefruit juice or are taking medications that may include:

Verapamil

Cyclosporine

CiprOfloxacin

Fluconazole

fluvoxamine

It is not known if it is safe to take ubrogepant for more than 8 migraine headaches in 30 days.

You should write down when you have headaches and when you take ubrogepant so you can talk to your healthcare provider about how ubrogepant is working for you.

If you take too much ubrogepant, call your healthcare provider or go to the nearest hospital emergency room right away.

What other drugs will affect Ubrogepant

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take any of the following, as your healthcare provider may need to change the dose of ubrogepant:

Verapamil

cyclosporine

ciprofloxacin

Fluconazole

fluvoxamine

Phenytoin

Barbiturates

Rifampin

St. John’s Wort

Quinidine

Carvedilol

Eltrombopag

curcumin

These are not all of the medicines that could affect how ubrogepant works. Your healthcare provider can tell you if it is safe to take ubrogepant with other medicines.

Disclaimer

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