Umbralisib

Generic name: Umbralisib
Brand names: Ukoniq
Dosage form: oral tablet (200 mg)
Drug class: Multikinase inhibitors

Usage of Umbralisib

Umbralisib is used to treat certain types of lymphoma in adults.

Umbralisib is given after other cancer treatments did not work or have stopped working.

Umbralisib may also be used for purposes not listed in this medication guide.

Umbralisib side effects

Get emergency medical help if you have signs of an allergic Reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Umbralisib may cause serious side effects. Call your doctor at once if you have:

a severe skin rash, or sores on your skin or mouth;

severe or ongoing diarrhea, stools with mucus or blood, or severe stomach pain;

liver problems--stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects of umbralisib may include:

low blood cell counts;

nausea, vomiting, stomach pain, loss of appetite;

cold symptoms such as stuffy nose, sneezing, sore throat;

muscle or bone pain;

feeling tired; or

abnormal kidney function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Umbralisib

Tell your doctor if you have and infection, or if you've ever had:

a stomach or intestinal disorder;

liver problems; or

an allergy to aspirin or yellow food dye.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using umbralisib should use effective birth control to prevent pregnancy. Umbralisib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using umbralisib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because umbralisib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Relate drugs

How to use Umbralisib

Usual Adult Dose for Lymphoma:

800 mg orally once a dayComments: -Patients should be provided with prophylaxis for Pneumocystis jirovecii pneumonia (PJP) during treatment.-Consideration should be given to provide prophylactic antivirals during treatment with to prevent cytomegalovirus (CMV) infection, including CMV reactivation.-Treatment should be continued until disease progression or unacceptable toxicity.Uses: -For the treatment of adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least one prior anti-CD20-based regimen-For the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) who have received at least three prior lines of systemic therapy

Usual Adult Dose for Follicular Lymphoma:

Warnings

Umbralisib affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, or other flu-like symptoms

Get emergency medical help if you have signs of a severe skin reaction such as a fever with skin rash, itching, blistering, peeling, or sores on your skin or mouth.

What other drugs will affect Umbralisib

Other drugs may affect umbralisib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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