Valbenazine
Generic name: Valbenazine
Brand names: Ingrezza
Dosage form: oral capsule
Drug class:
VMAT2 inhibitors
Usage of Valbenazine
Valbenazine is a drug used to treat a side effect of antipsychotic or neuroleptic medications called tardive dyskinesia.
Tardive dyskinesia is a movement disorder that causes uncontrollable abnormal movements of the jaw, lips and tongue. It is a rare side effect that may occur after long-term use of certain medications that block doPamine receptors, leading to too much dopamine signaling in the brain. These medications are used to treat schizophrenia and other conditions.
Dopamine is a chemical messenger called a monoamine neurotransmitter. It communicates information between nerve cells and and is involved in many bodily functions including movement and mood.
Valbenazine is a type of drug called a VMAT2 (vesicular monoamine transporter 2) inhibitor. It is thought to work by preventing the release of dopamine from small structures (vesicles) within dopamine-producing nerve cells, which reduces extra dopamine signaling in the brain.
Valbenazine is used to treat the symptoms of tardive dyskinesia, but it does not cure the condition. It was approved by the US Food and Drug Administration in 2017.
Valbenazine side effects
Valbenazine may cause serious side effects, including:
The most common side effect of valbenazine is sleepiness (somnolence).
Other common side effects include:
These are not all of the possible side effects of valbenazine. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Valbenazine
Tell your healthcare provider is you are pregnant or plan to become pregnant. Valbenazine may harm your unborn baby.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if valbenazine passes into your breast milk. Do not breastfeed during treatment with valbenazine and for 5 days after the final dose. Talk to your healthcare provider about the best way to feed your baby during treatment with valbenazine.
Relate drugs
How to use Valbenazine
What other drugs will affect Valbenazine
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Using valbenazine at the SAMe time as a monoamine oxide inhibitor (MAOI) should be avoided. Examples of MAOIs include:
Taking valbenazine with certain other medicines may cause serious side effects. Do not start any new medicines while taking valbenazine without talking to your healthcare provider first.
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