Valchlor

Generic name: Mechlorethamine Topical
Drug class: Topical antineoplastics

Usage of Valchlor

Valchlor gel is used to treat Stage 1A or 1B mycosis fungoides-type cUTAneous T-cell lymphoma.

Valchlor gel is usually used after other skin treatments have been tried without success.

Valchlor may also be used for purposes not listed in this medication guide.

Valchlor side effects

Get emergency medical help if you have any signs of an allergic Reaction to Valchlor gel: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a new skin lesion;
  • severe skin irritation, itching, or blistering; or
  • redness or swelling, warmth, pus, oozing, or other signs of skin infection.

    • Common Valchlor side effects may include:

  • mild skin itching or other irritation; or
  • changes in the color of treated skin.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Valchlor

    You should not use Valchlor if you are allergic to Mechlorethamine.

    Valchlor can be dangerous if it gets on the skin of another person. Caregivers should wear disposable gloves while applying this medication to the person who is affected with cutaneous T-cell lymphoma.

    Using this medicine may increase your risk of developing other types of skin cancer. Your doctor will need to check your skin on a regular basis while you are using Valchlor.

    Do not use Valchlor gel if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine, and tell your doctor if you become pregnant during treatment.

    It is not known whether mechlorethamine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

    Relate drugs

    How to use Valchlor

    Usual Adult Dose for Malignant Disease:

    0.4 mg/kg IV once a month or 0.2 mg/kg IV once a day for 2 days or 0.1 mg/kg IV once a day for 4 days or 6 mg/m² IV on days 1 and 8 of a 28 day cycle, as part of the MOPP regimen for Hodgkin's disease or 0.4 mg/kg intracavity injection one time or 0.2 mg/kg intraperIcardial injection one time.

    Usual Adult Dose for Mycosis Fungoides:

    0.01% topically once a day.

    Usual Pediatric Dose for Malignant Disease:

    Child: 0.4 mg/kg IV once a month or 0.2 mg/kg IV once a day for 2 days or 0.1 mg/kg IV once a day for 4 days or 6 mg/m² IV on days 1 and 8 of a 28 day cycle, as part of the MOPP regimen for Hodgkin's disease or 0.4 mg/kg intracavity injection one time or 0.2 mg/kg intrapericardial injection one time.

    Warnings

    Avoid getting Valchlor in your eyes. Valchlor gel can cause blindness or permanent injury to your eyes. If this medication gets in your eyes, rinse them for at least 15 minutes with a large amount of water, normal saline, or an eye wash solution, and then seek emergency medical attention.

    Avoid getting this medication in your mouth or nose. If this does happen, rinse for at least 15 minutes with a large amount of water and seek emergency medical attention. Valchlor can cause pain, redness, or ulcers if it gets in your mouth or nose.

    Always get emergency medical help if this medication accidentally gets in your eyes, nose, or mouth.

    What other drugs will affect Valchlor

    It is not likely that other drugs you take orally or inject will have an effect on topically applied mechlorethamine. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

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