Valrubicin

Generic name: Valrubicin
Brand names: Valstar
Dosage form: intravesical solution (40 mg/mL)
Drug class: Antibiotics / antineoplastics

Usage of Valrubicin

Valrubicin is used to treat bladder cancer that has not spread to other parts of the body.

Most people do not have a complete response to valrubicin. You may eventually need surgery to remove your bladder to keep the cancer from becoming metastatic (spreading to other parts of your body).

Valrubicin may also be used for purposes not listed in this medicine guide.

Valrubicin side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Valrubicin may cause serious side effects. Call your doctor at once if you have:

  • blood in your urine or painful urination lasting for longer than 24 hours;
  • pain or burning when you urinate; or
  • low white blood cell counts (about 1 week after a valrubicin injection)--fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

    • Common side effects of valrubicin may include:

  • red or pink urine within the first 24 hours after you receive valrubicin;
  • increased urge to urinate, urine leakage;
  • painful or difficult urination;
  • bladder pain;
  • increased urination at night; or
  • nausea, stomach pain.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Valrubicin

    You should not be treated with valrubicin if you are allergic to it, or if you have:

  • a urinary tract infection;
  • bladder perforation (a hole or tear); or
  • an allergy to polyoxyl Castor oil, or to other cancer medicines (Daunorubicin, doxorubicin, epirubicin, Idarubicin, mitoxantrone).

    • Tell your doctor if you have ever HAD:

  • overactive bladder, incontinence or leakage;
  • bladder surgery; or
  • trouble holding a large amount of urine in your bladder.

    • It may be harder for you to get a woman pregnant while you are using valrubicin. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

    Valrubicin can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use valrubicin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using valrubicin.

    • Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

    Relate drugs

    How to use Valrubicin

    Usual Adult Dose for Urinary Tumor:

    Usual Adult Dose: 800 mg administered intravesically once a week for six weeks.Comments: -Delay administration at least two weeks after transurethral resection and/or fulguration.-Patients should retain the drug for two hours before voiding, if they are able. At the end of two hours, all patients should void. Use: For intravesical therapy of BCG-refractory carcinoma in situ (CIS) of the urinary bladder in patients for whom immediate cystectomy would be associated with uNACceptable morbidity or mortality.

    Warnings

    You may not have a complete response to valrubicin, and your bladder may need to be surgically removed to prevent your cancer from spreading to other parts of your body.

    What other drugs will affect Valrubicin

    Because valrubicin is not absorbed into the bloodstream, it is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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