Vanatrip

Generic name: Amitriptyline
Drug class: Tricyclic antidepressants

Usage of Vanatrip

Amitriptyline is used to treat symptoms of depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. This medicine is a tricyclic antidepressant (TCA).

This medicine is available only with your doctor's prescription.

Vanatrip side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness

changes in patterns and rhythms of speech

chest pain or discomfort

chills

cold sweats

coma

confusion

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in frequency of urination

decrease in urine volume

decreased urine output

difficulty in breathing

difficulty in passing urine (dribbling)

difficulty in speaking

disturbance of accommodation

disturbed concentration

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision

drooling

dry mouth

excitement

fainting

false beliefs that cannot be changed by facts

fast, slow, or irregular heartbeat

fear or nervousness

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

high fever

high or low blood pressure

hostility

inability to move arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased ocular pressure

increased sweating

increased thirst

increased urination

irritability

lack of coordination

lethargy

light-colored stools

lip smacking or puckering

loss of appetite

loss of balance control

loss of bladder control

loss of consciousness

lower back or side pain

mental depression or anxiety

muscle spasm or jerking of all extremities

muscle tightness

muscle trembling, jerking, or stiffness

muscle twitching

nausea and vomiting

nightmares or unusually vivid dreams

overactive reflexes

painful or difficult urination

passing urine more often

pinpoint red spots on skin

poor coordination

pounding in the ears

puffing of cheeks

rapid or worm-like movements of tongue

rapid weight gain

restlessness

seeing, hearing, or feeling things that are not there

seizures

severe muscle stiffness

shakiness and unsteady walk

shivering

shortness of breath

shuffling walk

sleeplessness

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on lips or in mouth

stiffness of limbs

stupor

sudden loss of consciousness

sweating

swelling of face, ankles, or hands

swelling or puffiness of face

swollen glands

talking or acting with excitement you cannot control

trouble in speaking

trouble sleeping

troubled breathing

twisting movements of body pain or discomfort in arms, jaw, back, or neck

unable to sleep

uncontrolled chewing movements

uncontrolled movements, especially of arms, face, neck, back, and legs

unexplained weight loss

unpleasant breath odor

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual tiredness or weakness

unusually pale skin

upper right abdominal pain

vomiting of blood

weakness in arms, hands, legs, or feet

weight gain or loss

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

Clumsiness

drowsiness

low body temperature

muscle aches

muscle weakness

sleepiness

tiredness

weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bigger, dilated, or enlarged pupils (black part of eye)

black tongue

bloating

breast enlargement in females

constipation

decreased interest in sexual intercourse

diarrhea

hair loss, thinning of hair

hives or welts

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity of eyes to light

loss in sexual ability, desire, drive, or performance

loss of sense of taste

redness or other discoloration of skin

severe sunburn

skin rash

swelling of testicles

swelling of the breasts or breast soreness in males

swelling of the parotid glands

swelling or inflammation of the mouth

unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Vanatrip

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic Reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amitriptyline in children below 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amitriptyline in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require an adjustment in the dose for patients receiving amitriptyline.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Bromopride

Cisapride

Clorgyline

Dronedarone

Furazolidone

Grepafloxacin

Iproniazid

Isocarboxazid

Levoketoconazole

Levomethadyl

Linezolid

Mesoridazine

Methylene Blue

Metoclopramide

Moclobemide

Nialamide

Pargyline

Phenelzine

Pimozide

Piperaquine

Potassium Citrate

Procarbazine

Ranolazine

Safinamide

Saquinavir

Selegiline

Sparfloxacin

Terfenadine

Thioridazine

Toloxatone

Tranylcypromine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Aceclofenac

Acemetacin

Adagrasib

Albuterol

Alfentanil

Alfuzosin

Almotriptan

Amantadine

Amiodarone

Amisulpride

Amoxapine

Amphetamine

Amtolmetin Guacil

Anagrelide

Apomorphine

Aprindine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Asenapine

Aspirin

Astemizole

Atazanavir

Azimilide

Azithromycin

Benzhydrocodone

Benzphetamine

Bretylium

Bromfenac

Brompheniramine

Bufexamac

Buprenorphine

Bupropion

Buserelin

Buspirone

Butorphanol

Carisoprodol

Celecoxib

Ceritinib

Chloral Hydrate

Chloroquine

Chlorpheniramine

Chlorpromazine

Choline Salicylate

CiprOfloxacin

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clonidine

Clonixin

Clothiapine

Clozapine

Cocaine

Codeine

Crizotinib

Cyclobenzaprine

Dabrafenib

Darunavir

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Desmopressin

Desvenlafaxine

Deutetrabenazine

Dexibuprofen

Dexketoprofen

Dexmedetomidine

Dextroamphetamine

Dextromethorphan

Diclofenac

Diflunisal

Dihydrocodeine

Dipyrone

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Droxicam

Duloxetine

Efavirenz

Eletriptan

Encorafenib

Enflurane

Entrectinib

Epinephrine

Erythromycin

Escitalopram

Eslicarbazepine Acetate

Etodolac

Etofenamate

Etoricoxib

Etrasimod

Fedratinib

Felbinac

Fenfluramine

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Fexinidazole

Fingolimod

Flecainide

Floctafenine

Fluconazole

Flufenamic Acid

Fluoxetine

Flurbiprofen

Fluvoxamine

Formoterol

Foscarnet

Fostemsavir

Frovatriptan

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Halothane

Histrelin

Hydrocodone

Hydromorphone

Hydroxyamphetamine

Hydroxychloroquine

Hydroxytryptophan

Hydroxyzine

Ibuprofen

Ibutilide

Iloperidone

Imipramine

Indomethacin

Inotuzumab Ozogamicin

Iobenguane I 123

Iobenguane I 131

Isoflurane

Isradipine

Ivabradine

Ivosidenib

Ketoconazole

Ketoprofen

Ketorolac

Lacosamide

Lapatinib

Lasmiditan

Lefamulin

Lenvatinib

Leuprolide

Levalbuterol

Levofloxacin

Levomilnacipran

Levorphanol

Lidoflazine

Lisdexamfetamine

Lithium

Lofexidine

Lopinavir

Lorcainide

Lorcaserin

Lornoxicam

Loxapine

Loxoprofen

Lumefantrine

Lumiracoxib

Macimorelin

Meclofenamate

Mefenamic Acid

Mefloquine

Meloxicam

Meperidine

Metaxalone

Methacholine

Methadone

Methamphetamine

Metronidazole

Milnacipran

Mirtazapine

Mobocertinib

Moricizine

Morniflumate

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nabumetone

Nafarelin

Nalbuphine

Naproxen

Naratriptan

Nefazodone

Nefopam

Nepafenac

Niflumic Acid

Nilotinib

Nimesulide

Nimesulide Beta Cyclodextrin

Norepinephrine

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Oxaprozin

Oxycodone

Oxymetazoline

Oxymorphone

Oxyphenbutazone

Ozanimod

Pacritinib

Paliperidone

Palonosetron

Panobinostat

Parecoxib

Paroxetine

Pasireotide

Pazopanib

Peginterferon Alfa-2b

Pentamidine

Pentazocine

Phenylbutazone

Piketoprofen

Pimavanserin

Piroxicam

Pitolisant

Pixantrone

Ponesimod

Posaconazole

Pranoprofen

Procainamide

Prochlorperazine

Proglumetacin

Promethazine

Propafenone

Propoxyphene

Propyphenazone

Proquazone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Rasagiline

Relugolix

Remifentanil

Revefenacin

Ribociclib

Risperidone

Rizatriptan

Rofecoxib

Salicylic Acid

Salsalate

Scopolamine

Secretin Human

Selpercatinib

Sematilide

Sertindole

Sertraline

Sevoflurane

Sibutramine

Siponimod

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Sodium Salicylate

Solifenacin

Sorafenib

Sotalol

Spiramycin

Sufentanil

Sulfamethoxazole

Sulindac

Sulpiride

Sultopride

Sumatriptan

Sunitinib

Tacrolimus

Tapentadol

Tedisamil

Telavancin

Telithromycin

Tenoxicam

Tetrabenazine

Tiaprofenic Acid

Tiotropium

Tolfenamic Acid

Tolmetin

Topiramate

Toremifene

Tramadol

Trazodone

Triclabendazole

Trifluoperazine

Trimethoprim

Trimipramine

Triptorelin

Tryptophan

Valdecoxib

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Vilanterol

Vilazodone

Vinflunine

Voclosporin

Voriconazole

Vortioxetine

Zolmitriptan

Zotepine

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol

Arbutamine

Atomoxetine

Bethanidine

Carbamazepine

Cimetidine

DesOgestrel

Diazepam

Dicumarol

Dienogest

Drospirenone

Ethinyl Estradiol

Ethynodiol

Fosphenytoin

Galantamine

Gestodene

Guanethidine

Levonorgestrel

Mestranol

Nomegestrol

Norethindrone

Norgestimate

Norgestrel

Phenprocoumon

Phenytoin

Rifapentine

Ritonavir

S-Adenosylmethionine

St John's Wort

Valproic Acid

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Relate drugs

How to use Vanatrip

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a medication guide. Read and follow the instructions in the guide carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets):

For depression:

Adults—At first, 75 milligrams (mg) per day given in divided doses, or 50 to 100 mg at bedtime. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses.

Teenagers and Older adults—10 milligrams (mg) three times a day, and 20 mg at bedtime. Your doctor may adjust your dose as needed.

Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Do not take amitriptyline if you have taken a monoamine oxidase (MAO) inhibitor (isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], or tranylcypromine [Parnate®]) in the past 2 weeks. Do not start taking a MAO inhibitor within 5 days of stopping amitriptyline. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, or severe convulsions.

Do not take other medicines unless they have been discussed with your doctor. Using this medicine together with cisapride (Propulsid®), may increase the chance of having serious side effects.

Do not suddenly stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, or a general feeling of discomfort or illness.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.

Before having any kind of surgery, tell the medical doctor in charge that you are using this medicine. Taking amitriptyline together with medicines used during surgery may increase the risk of side effects.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

This medicine may cause some people to become drowsy. Make sure you know how you react to this medicine before you drive, use medicines, or do anything else that could be dangerous if you are drowsy or not alert .

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