Vemurafenib
Generic name: Vemurafenib
Brand names: Zelboraf
Dosage form: oral tablet (240 mg)
Drug class:
Multikinase inhibitors
Usage of Vemurafenib
Vemurafenib is used to treat melanoma (skin cancer) that has spread to other parts of the body or cannot be removed by surgery.
Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer).
Vemurafenib is used only if your cancer has a specific genetic marker (an abnormal "BRAF" gene). Your doctor will test you for this gene.
Vemurafenib may also be used for purposes not listed in this medication guide.
Vemurafenib side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Vemurafenib may cause serious side effects. Stop using vemurafenib and call your doctor at once if you have:
Common side effects of vemurafenib may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Vemurafenib
You should not use vemurafenib if you are allergic to it.
Tell your doctor if you have ever had:
Tell your doctor about all radiation treatments you are scheduled to receive, or have received in the past.
Using vemurafenib may increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.
Vemurafenib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, and for 2 weeks after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
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How to use Vemurafenib
Usual Adult Dose for Melanoma -- Metastatic:
960 mg orally every 12 hours until disease progression or unacceptable toxicity Comments:-Confirm the presence of BRAF V600E mutation in tumor specimens prior to initiation of therapy.Use: BRAF V600 mutation-positive unresectable or metastatic melanoma
Usual Adult Dose for Histiocytosis:
960 mg orally every 12 hours until disease progression or unacceptable toxicity Comments:-Confirm the presence of BRAF V600E mutation in tumor specimens prior to initiation of therapy.Use: For Erdheim-Chester Disease (ECD) with BRAF V600 mutation
Warnings
Vemurafenib is used to treat melanoma, but vemurafenib can increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.
Many drugs can interact with vemurafenib. Tell your doctor about all your current medicines and any you start or stop using
What other drugs will affect Vemurafenib
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect vemurafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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