Venlafaxine

Generic name: Venlafaxine
Drug class: Serotonin-norepinephrine reuptake inhibitors

Usage of Venlafaxine

Venlafaxine is used in adults to treat major depressive disorder. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks).

Venlafaxine belongs to in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Venlafaxine works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.

Venlafaxine side effects

Get emergency medical help if you have signs of an allergic reaction to venlafaxine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Venlafaxine may cause serious side effects. Call your doctor at once if you have:

blurred vision, eye pain or redness, seeing halos around lights;

cough, chest tightness, trouble breathing;

a seizure (convulsions);

unusual bleeding - nosebleeds, bleeding gums, abnormal vaginal bleeding, any bleeding that will not stop;

low blood sodium - headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or

severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common venlafaxine side effects may include:

headache, dizziness, drowsiness, tiredness;

ringing in your ears, feeling anxious, nervous, or jittery;

sleep problems, unusual dreams;

tremors;

fast heartbeats;

blurred vision;

nausea, vomiting, diarrhea, constipation;

changes in weight or appetite;

dry mouth, yawning;

increased sweating; or

sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Venlafaxine

You should not take venlafaxine if you are allergic to it or to desvenlafaxine (Pristiq).

Do not use venlafaxine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with venlafaxine could cause a serious condition called serotonin syndrome.

To make sure venlafaxine is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic depression);

heart disease, high blood pressure, high cholesterol or triglycerides;

diabetes;

lung disease;

glaucoma;

a thyroid disorder;

a seizure;

sexual problems;

bleeding problems;

low blood levels of sodium; or

liver or kidney disease.

Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop venlafaxine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of venlafaxine on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Relate drugs

How to use Venlafaxine

Usual Adult Dose for Depression:

Immediate release: -Initial dose: 37.5 mg orally twice a day OR 25 mg orally 3 times a day -Maintenance dose: 75 to 150 mg orally per day, given in divided doses -Maximum dose: ---Moderately depressed outpatients: 225 mg/day ---Severely depressed inpatients: 375 mg/day Extended release: -Initial dose: 75 mg orally once a day -Maintenance dose: 75 to 225 mg orally once a day -Maximum dose: ---Moderately depressed outpatients: 225 mg/day ---Severely depressed inpatients: 375 mg/day Comments: -The daily dosage of immediate-release formulations may be divided into 2 or 3 doses/day. -Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug. -Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days. -Patients should be periodically reassessed for the continued need of maintenance treatment and for the appropriate dose of treatment. -Use of doses exceeding 225 mg/day is limited.

Usual Adult Dose for Generalized Anxiety Disorder:

Extended release: -Initial dose: 75 mg orally once a day -Maintenance dose: 75 to 225 mg orally once a day -Maximum dose: 225 mg/day Comments: -Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug. -Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days.

Usual Adult Dose for Social Anxiety Disorder:

Extended release: 75 mg orally once a day Comment: There is no evidence that doses greater than 75 mg/day confer additional benefit.

Usual Adult Dose for Panic Disorder:

Extended release: -Initial dose: 37.5 mg orally once a day for 7 days, then 75 mg orally once a day thereafter -Maintenance dose: 75 to 225 mg orally once a day -Maximum dose: 225 mg/day Comment: Doses may be increased in daily increments of 75 mg orally at intervals of no less than 7 days.

Warnings

You should not take venlafaxine if you have uncontrolled narrow-angle glaucoma.

Do not use venlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not stop using venlafaxine without first talking to your doctor.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Venlafaxine is not FDA approved for use in children.

What other drugs will affect Venlafaxine

Using venlafaxine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can affect venlafaxine, especially:

any other antidepressant;

amphetamines;

fentanyl;

cimetidine;

tramadol;

St. John's wort, tryptophan (sometimes called L-tryptophan);

diet pills, weight loss medicine (such as phentermine);

a blood thinner (warfarin, Coumadin, Jantoven);

medicine to treat mood disorders, thought disorders, or mental illness - buspirone, lithium, and many others; or

migraine headache medicine - sumatriptan, zolmitriptan, and others.

This list is not complete and many other drugs may interact with venlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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