Veozah

Generic name:  fezolinetant
Dosage form: tablets, for oral use
Drug class: Miscellaneous central nervous system agents

Usage of Veozah

Veozah is a nonhormonal prescription medicine used to reduce moderate to severe vasomotor symptoms (hot flashes and night sweats) due to menopause. 

Before a woman enters menopause, a balance exists between the estrogen hormones and a brain chemical called neurokinin B (NKB), that works to regulate the body’s temperature. During menopause, estrogen levels decline and this balance is disrupted, leading to vasomotor symptoms.

Veozah contains a drug called fezolinetant. Fezolinetant is a neurokinin 3 (NK3) receptor antagonist that works to reduce the frequency and intensity of hot flashes by restoring the balance between estrogen and NKB by blocking NKB in the temperature control center of the brain.

Veozah side effects

Veozah can cause serious side effects, including:

  • increased liver blood test values. Your healthcare provider will do a blood test to check your liver before you start treatment. Your healthcare provider will also do this blood test at month 3, month 6, and month 9 after you start taking Veozah.

    • Call your healthcare provider right away if you have the following signs and symptoms of liver problems:

  • nausea
  • vomiting
  • yellowing of the eyes or skin (jaundice)
  • pain in the right upper stomach (abdomen)

    • Common Veozah side effects include:

  • stomach (abdominal) pain
  • diarrhea
  • difficulty sleeping (insomnia)
  • back pain
  • hot flashes or hot flushes

    • Tell your healthcare provider if you have any side effect that bothers you or does not go away.

    These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Veozah

    Do not use Veozah if you:

  • have cirrhosis.
  • have severe kidney problems or kidney failure.
  • are taking certain medicines called CYP1A2 inhibitors. Ask your healthcare provider if you are not sure.

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    How to use Veozah

    Usual Adult Dose for Vasomotor Symptoms Due to Menopause

    45 mg orally once daily

    Use: - treatment of moderate to severe vasomotor symptoms due to menopause.

    What other drugs will affect Veozah

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Veozah may affect the way other medicines work, and vice versa. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

    Especially tell your healthcare provider if you are taking certain medicines called CYP1A2 inhibitors.

    CYP1A2 inhibitors include:

  • fluvoxamine
  • ciprofloxacin
  • enoxacin
  • methoxsalen
  • mexiletine
  • oral contraceptives
  • vemurafenib
  • acyclovir
  • allopurinol
  • cimetidine
  • peginterferon alpha-2a
  • piperine
  • zileuton

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