Versed (Midazolam Injection)

Generic name: Midazolam
Drug class: Benzodiazepines

Usage of Versed (Midazolam Injection)

Midazolam injection is used to produce sleepiness or drowsiness and relieve anxiety before surgery or certain procedures. When midazolam is used before surgery, the patient will not remember some of the details about the procedure. Midazolam injection is also used as an anesthesia to produce loss of consciousness before and during surgery.

Midazolam injection is also used to treat status epilepticus, a severe type of seizure where there is more than one seizure within 5 minutes.

Midazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is given only by or under the direct supervision of your doctor.

Versed (Midazolam Injection) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Aggressiveness

agitation

anxiety

choking

confusion

decreased awareness or responsiveness

decreased urine output

difficulty walking, speaking, or writing

discouragement

dizziness

feeling sad or empty

fever

headache

irritability

lack of appetite

loss of bladder or bowel control

loss of consciousness

loss of interest or pleasure

memory loss

muscle twitching

nausea

nightmares or unusually vivid dreams

rapid weight gain

seizures

severe sleepiness

strong urge to urinate

swelling of the face, ankles, or hands

thirst

trouble concentrating

trouble sleeping

trouble breathing

unable to speak

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation

changes in patterns and rhythms of speech

confusion

excitement

irritability

lack of coordination

loss of strength or energy

muscle pain or weakness

relaxed and calm feeling

restlessness

shakiness and unsteady walk

slurred speech

talkativeness

trouble in speaking

unsteadiness, trembling, or other problems with muscle control or coordination

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

unusual weak feeling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Rare

Muscle stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Versed (Midazolam Injection)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of midazolam injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of midazolam injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amprenavir

Atazanavir

Boceprevir

Cobicistat

Darunavir

Delavirdine

Flumazenil

Fosamprenavir

Indinavir

Itraconazole

Levoketoconazole

Lopinavir

Nelfinavir

Saquinavir

Telaprevir

Tipranavir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adagrasib

Alfentanil

Alprazolam

Amobarbital

Anileridine

Aprobarbital

Aripiprazole

Baclofen

Belzutifan

Benzhydrocodone

Bromazepam

Bromopride

Buprenorphine

Buspirone

Butabarbital

Butalbital

Butorphanol

Calcium Oxybate

Cannabis

Ceritinib

Cetirizine

Chloral Hydrate

Chlordiazepoxide

Chlorpromazine

Chlorzoxazone

Ciprofloxacin

Clarithromycin

Clobazam

Clonazepam

Clorazepate

Codeine

Conivaptan

Cyclobenzaprine

Dabrafenib

Dantrolene

Daridorexant

Dexmedetomidine

Dezocine

Diacetylmorphine

Diazepam

Difenoxin

Dihydrocodeine

Diphenhydramine

Diphenoxylate

Doxylamine

Dronedarone

Duvelisib

Esketamine

Estazolam

Eszopiclone

Ethchlorvynol

Ethylmorphine

Fedratinib

Fentanyl

Fexinidazole

Flibanserin

Fluconazole

Flunitrazepam

Flurazepam

Fosnetupitant

Fospropofol

Gabapentin

Gabapentin Enacarbil

Halazepam

Hydrocodone

Hydromorphone

Hydroxyzine

Idelalisib

Imatinib

Isavuconazonium Sulfate

Ivacaftor

Ivosidenib

Ketamine

Ketazolam

Ketobemidone

Lacosamide

Larotrectinib

Lefamulin

Lemborexant

Lenacapavir

Letermovir

Levocetirizine

Levorphanol

Lofexidine

Lorazepam

Lorlatinib

Loxapine

Lumacaftor

Magnesium Oxybate

Mavacamten

Meclizine

Meperidine

Mephenesin

Mephobarbital

Meprobamate

Meptazinol

Metaxalone

Methadone

Methocarbamol

Methohexital

Methotrimeprazine

Metoclopramide

Mirtazapine

Morphine

Morphine Sulfate Liposome

Nalbuphine

Nefazodone

Netupitant

Nicomorphine

Nilotinib

Nitrazepam

Olutasidenib

Omaveloxolone

Opium

Opium Alkaloids

Orlistat

Orphenadrine

Oxazepam

Oxycodone

Oxymorphone

Pacritinib

Papaveretum

Paregoric

Pentazocine

Pentobarbital

Perampanel

Periciazine

Phenobarbital

Piritramide

Pirtobrutinib

Posaconazole

Potassium Oxybate

Prazepam

Pregabalin

Primidone

Promethazine

Propofol

Quazepam

Ramelteon

Remifentanil

Remimazolam

Ribociclib

Ritlecitinib

Ropeginterferon Alfa-2b-njft

Scopolamine

Secobarbital

Sodium Oxybate

Sufentanil

Tapentadol

Temazepam

Thiopental

Thioridazine

Tilidine

Tizanidine

Tocilizumab

Topiramate

Tramadol

Trazodone

Triazolam

Trofinetide

Zaleplon

Zolpidem

Zopiclone

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aprepitant

Armodafinil

Carbamazepine

Cimetidine

Crizotinib

Cyclosporine

Dalfopristin

Diltiazem

Echinacea

Erythromycin

Fluvoxamine

Fosaprepitant

Fosphenytoin

Ginkgo Biloba

Goldenseal

Halothane

Laropiprant

Mitotane

Phenytoin

Quinupristin

Rifapentine

Roxithromycin

St John's Wort

Telithromycin

Theophylline

Verapamil

Voriconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Relate drugs

How to use Versed (Midazolam Injection)

A nurse or other trained health professional will give you this medicine. It is given as a shot into one of your muscles.

After you receive a shot of this medicine, your doctor will watch you closely to make sure it is working properly and to check for unwanted effects.

Warnings

It is very important that your doctor check your progress closely after you receive this medicine to make sure it is working properly and to check for any unwanted effects.

Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine during the later pregnancy may cause problems in your newborn baby (eg, sedation or withdrawal symptoms). Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, feeding problems, a high-pitched cry, irritability, low muscle tone, restlessness, shakiness or tremors, sluggishness, trouble breathing, weight loss, vomiting, or fails to gain weight. If you think you have become pregnant while using the medicine, tell your doctor right away.

Symptoms of an overdose include: change or loss of consciousness, confusion, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, irregular, fast or slow, or shallow breathing, lack of coordination, loss of strength or energy, muscle pain or weakness, pale or blue lips, fingernails, or skin, shakiness and unsteady walk, unsteadiness, trembling, or other problems with muscle control or coordination, sweating, trouble breathing, unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness, or unusual weak feeling. Call your doctor right away if you notice these symptoms.

This medicine may cause respiratory depression (serious breathing problem that can be life-threatening), especially when used with narcotic pain medicines. Tell your doctor if you are using any narcotic medicine, such as droperidol, fentanyl, meperidine, morphine, or secobarbital.

This medicine contains Benzyl Alcohol which may cause serious reactions to newborn, premature, or low-birthweight infants. Talk this with your doctor if you are concerned.

This medicine may cause drowsiness, trouble with thinking, trouble with controlling movements, or trouble with seeing clearly. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Check with your doctor right away if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates (used for seizures), muscle relaxants, or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before using any of the above while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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