Viberzi

Generic name: Eluxadoline
Drug class: Peripheral opioid receptor mixed agonists / antagonists

Usage of Viberzi

Viberzi works directly in your intestines to slow the movement of food during digestion. Eluxadoline also makes the nerves in your intestines less sensitive to stimulation.

Viberzi is used to treat irritable bowel syndrome when the main symptom is diarrhea.

Viberzi may also be used for purposes not listed in this medication guide.

Viberzi side effects

Get emergency medical help if you have signs of an allergic reaction to Viberzi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medicine and call your doctor at once if you have:

new or worsening stomach pain (may be severe);

nausea and vomiting;

severe constipation;

constipation lasting longer than 4 days; or

severe pain in your upper stomach spreading to your back.

Side effects may be more likely in older adults.

Common Viberzi side effects may include:

constipation;

nausea; or

stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Viberzi

You should not use Viberzi if you are allergic to eluxadoline, or if you have:

severe constipation or a blockage in your intestines;

a history of gallbladder obstruction, or if your gallbladder has been removed;

digestive problems caused by a muscle valve called the sphincter of Oddi (SFINK-ter of OD-dee);

severe liver disease;

a pancreas disorder; or

a habit of drinking more than 3 alcoholic beverages per day.

To make sure Viberzi is safe for you, tell your doctor if you have ever had:

liver disease; or

kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

Viberzi is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Viberzi

Usual Adult Dose for Irritable Bowel Syndrome:

Usual dose: 100 mg orally twice a day Comments: -Dose should be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose. -If severe constipation develops, this drug should be discontinued. Use: For the treatment of irritable bowel syndrome with diarrhea.

Warnings

You should not use Viberzi if you have a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or if your gallbladder has been removed.

Viberzi may cause pancreatitis or constipation, which could be severe or lead to hospitalization. Call your doctor at once if you have severe or ongoing constipation, severe pain in your upper stomach spreading to your back (with or without nausea and vomiting).

What other drugs will affect Viberzi

Tell your doctor about all your other medicines, especially:

alosetron or other medications to treat irritable bowel syndrome;

opioid pain medicine;

medicine to treat depression, anxiety, mood disorders, or mental illness;.

cold or allergy medicine (Benadryl and others);

medicine to treat Parkinson's disease;

medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

medicine to treat overactive bladder; or

bronchodilator asthma medication.

This list is not complete. Other drugs may interact with eluxadoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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