Viibryd Titration Pack

Generic name: Vilazodone
Drug class: Miscellaneous antidepressants

Usage of Viibryd Titration Pack

Vilazodone is used to treat depression in adults. It is an antidepressant and belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). Vilazodone works by increasing the activity of a chemical called serotonin in the brain.

This medicine is available only with your doctor's prescription.

Viibryd Titration Pack side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Actions that are out of control

anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

decreased interest in sexual intercourse

delayed or inability to have an orgasm

extra heartbeat

fast, irregular, pounding, or racing heartbeat or pulse

inability to have or keep an erection

irritability

loss in sexual ability, desire, drive, or performance

shakiness in the legs, arms, hands, or feet

sweating

talking, feeling, and acting with excitement

trembling or shaking of the hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

dizziness

dry mouth

nausea

trouble sleeping

Less common

Abnormal dreams

aching or discomfort in the lower legs or sensation of crawling in the legs

acid or sour stomach

belching

blindness

bloated or full feeling

blurred vision

change in taste

decreased vision

difficulty with moving

drowsiness

dry eyes

excess air or gas in the stomach or intestines

feeling jittery

headache, severe and throbbing

heartburn

increased or decreased appetite

increased sweating

indigestion

loss of appetite

loss of taste

muscle pain or stiffness

night sweats

pain in the joints

passing gas

relaxed and calm

restlessness

sleepiness or unusual drowsiness

stomach pain, discomfort, or upset

unusual tiredness or weakness

vomiting

weakness

Incidence not known

Decrease in smell

eye pain

loss of sense of smell

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Viibryd Titration Pack

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of vilazodone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of vilazodone in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood) and age-related liver, kidney, or heart problems which may require caution in patients receiving vilazodone.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Isocarboxazid

Linezolid

Methylene Blue

Metoclopramide

Ozanimod

Phenelzine

Procarbazine

Rasagiline

Safinamide

Selegiline

Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

ABCiximab

Aceclofenac

Acemetacin

Acenocoumarol

Alfentanil

Almotriptan

Amineptine

Amitriptyline

Amitriptylinoxide

Amoxapine

Amphetamine

Amtolmetin Guacil

Anagrelide

Anileridine

Apalutamide

Apixaban

Ardeparin

Argatroban

Aspirin

Bemiparin

Benzhydrocodone

Benzphetamine

Betrixaban

Bivalirudin

Boceprevir

Bromfenac

Brompheniramine

Bufexamac

Buprenorphine

Buspirone

Butorphanol

Cangrelor

Carbamazepine

Celecoxib

Ceritinib

Certoparin

Chlorpheniramine

Choline Salicylate

Cilostazol

Citalopram

Clarithromycin

Clomipramine

Clonixin

Clopidogrel

Cobicistat

Cocaine

Codeine

Colchicine

Conivaptan

Cyclobenzaprine

Cyclosporine

Dabigatran Etexilate

Dalteparin

Danaparoid

Darunavir

Desipramine

Desirudin

Desmopressin

Desvenlafaxine

Dexibuprofen

Dexketoprofen

Dextroamphetamine

Dextromethorphan

Dibenzepin

Diclofenac

Difenoxin

Diflunisal

Digoxin

Dihydrocodeine

Diphenoxylate

Dipyridamole

Dipyrone

Dolasetron

Doxepin

Drotrecogin Alfa

Droxicam

Duloxetine

Edoxaban

Eletriptan

Enoxaparin

Enzalutamide

Epoprostenol

Eptifibatide

Escitalopram

Ethylmorphine

Etodolac

Etofenamate

Etoricoxib

Everolimus

Felbinac

Fenfluramine

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Fluoxetine

Flurbiprofen

Fluvoxamine

Fondaparinux

Fosphenytoin

Frovatriptan

Gepirone

Granisetron

Heparin

Hydrocodone

Hydromorphone

Hydroxyamphetamine

Hydroxytryptophan

Ibuprofen

Idelalisib

Iloprost

Imipramine

Indinavir

Indomethacin

Iobenguane I 131

Itraconazole

Ivosidenib

Josamycin

Ketobemidone

Ketoconazole

Ketoprofen

Ketorolac

Lasmiditan

Lepirudin

Levomilnacipran

Levorphanol

Lisdexamfetamine

Lithium

Lofepramine

Lonafarnib

Lopinavir

Lorcaserin

Lornoxicam

Loxoprofen

Lumacaftor

Lumiracoxib

Meclofenamate

Mefenamic Acid

Melitracen

Meloxicam

Meperidine

Metaxalone

Methadone

Methamphetamine

Methylphenidate

Mibefradil

Mifepristone

Milnacipran

Mirtazapine

Mitotane

Morniflumate

Morphine

Morphine Sulfate Liposome

Nabumetone

Nadroparin

Nalbuphine

Naproxen

Naratriptan

Nefazodone

Nelfinavir

Nepafenac

Nicomorphine

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nortriptyline

Ondansetron

Opipramol

Opium

Opium Alkaloids

Oxaprozin

Oxycodone

Oxymorphone

Oxyphenbutazone

Palonosetron

Papaveretum

Parecoxib

Paregoric

Parnaparin

Paroxetine

Pentazocine

Phenprocoumon

Phenylbutazone

Phenytoin

Piketoprofen

Piritramide

Piroxicam

Posaconazole

Pranoprofen

Prasugrel

Proglumetacin

Propyphenazone

Proquazone

Protein C

Protriptyline

Remifentanil

Reviparin

Ribociclib

Rifampin

Rifapentine

Ritonavir

Rivaroxaban

Rizatriptan

Rofecoxib

Salicylic Acid

Salsalate

Saquinavir

Selexipag

Sertraline

Sibutramine

Sirolimus

Sodium Salicylate

St John's Wort

Sufentanil

Sulfinpyrazone

Sulindac

Sulodexide

Sumatriptan

Tacrolimus

Tapentadol

Telaprevir

Telithromycin

Tenoxicam

Tianeptine

Tiaprofenic Acid

Ticagrelor

Ticlopidine

Tilidine

Tinzaparin

Tirofiban

Tolfenamic Acid

Tolmetin

Tolvaptan

Tramadol

Trazodone

Treprostinil

Trimipramine

Troleandomycin

Tryptophan

Tucatinib

Valdecoxib

Venlafaxine

Vorapaxar

Voriconazole

Vortioxetine

Warfarin

Ziprasidone

Zolmitriptan

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Relate drugs

How to use Viibryd Titration Pack

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

It is best to take this medicine with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For treatment of depression:

Adults—At first, 10 milligrams (mg) as a single dose once a day for 7 days. Then, your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day.

Children—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is important that your doctor check your progress at regular visits to allow for changes in your dose and to help prevent any unwanted effects. Blood tests may be needed to check for unwanted effects.

Do not take vilazodone with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], methylene blue injection, phenelzine [Nardil®], selegiline [Eldepryl®], or tranylcypromine [Parnate®]). Do not start taking vilazodone during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping vilazodone before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures.

Vilazodone may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Vilazodone may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use vilazodone with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, amphetamines, or some pain or migraine medicines (eg, meperidine, methadone, rizatriptan, sumatriptan, tramadol, Demerol®, Methadose®, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Check with your doctor first before taking any other medicines with vilazodone.

This medicine may increase your risk for bleeding problems. Make sure your doctor knows if you are also taking other medicines that thin the blood, including aspirin, nonsteroidal antiinflammatory agents, also called NSAIDs (eg, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or warfarin (Coumadin®, Jantoven®).

Do not suddenly stop taking this medicine without checking first with your doctor. If you have been instructed to stop taking vilazodone, ask your doctor how to slowly decrease the dose. This will decrease your chance of having withdrawal symptoms, including dizziness, nausea, headaches, vomiting, increased sweating, irritability, nightmares, seizures, or prickling or tingling feelings.

Hyponatremia (low sodium in the blood) may occur with this medicine. This is more common in elderly patients, those who are taking diuretic medicines for high blood pressure, or those who have decreased amounts of fluid in the body due to severe diarrhea or vomiting. Check with your doctor right away if you have confusion, difficulty concentrating, headaches, memory problems, weakness, and unsteadiness.

The use of alcohol is not recommended in patients who are taking this medicine.

Vilazodone may cause some people to become dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Check with your doctor right away if you have decreased interest in sexual intercourse, delayed or inability to have an orgasm in women, inability to have or keep an erection in men, or loss in sexual ability, desire, drive, or performance. These could be symptoms of sexual dysfunction.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

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