Vinorelbine

Generic name: Vinorelbine
Brand names: Navelbine
Dosage form: intravenous solution (10 mg/mL)
Drug class: Mitotic inhibitors

Usage of Vinorelbine

Vinorelbine is used to treat non-small cell lung cancer, sometimes used in combination with other cancer medications.

Vinorelbine may also be used for other purposes not listed in this medication guide.

Vinorelbine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Vinorelbine may cause serious side effects. Call your doctor at once if you have:

severe constipation, stomach pain, bloody or black stools;

numbness, tingling, muscle weakness;

pain, redness, and peeling skin on your hands or feet;

new or worsening cough, wheezing, chest tightness, trouble breathing;

dark urine, jaundice (yellowing of the skin or eyes);

pain, burning, irritation, or skin changes where the injection was given; or

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Talk with your doctor about ways to avoid severe constipation while you are being treated with vinorelbine.

Common side effects of vinorelbine may include:

nausea, vomiting, constipation;

weakness;

numbness or tingling in your hands or feet;

low blood cell counts;

abnormal liver function tests; or

pain, redness, bruising, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Vinorelbine

You should not be treated with vinorelbine if you are allergic to it, or if you have severely low white blood cell counts.

Tell your doctor if you have ever had:

liver disease;

bone marrow suppression;

a nerve disorder; or

radiation therapy or other cancer treatments.

Vinorelbine can harm an unborn baby or cause birth defects if the mother or the father is using vinorelbine.

If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use vinorelbine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using vinorelbine.

Vinorelbine can damage sperm and it may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using vinorelbine, and for at least 9 days after your last dose.

Relate drugs

How to use Vinorelbine

Usual Adult Dose for Non-Small Cell Lung Cancer:

IN COMBINATION WITH CISPLATIN:25 mg/m2 IV over 6 to 10 minutes on Days 1, 8, 15, and 21 of a 28-day cycle in combination with cisplatin 100 mg/m2 IV on Day 1 only of each 28-day cycleOR30 mg/m2 IV over 6 to 10 minutes once a week in combination with cisplatin 120 mg/m2 IV on Days 1 and 29, then every 6 weeks AS A SINGLE AGENT: 30 mg/m2 IV over 6 to 10 minutes once a weekUses:-In combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) -As a single agent, for the treatment of patients with metastatic NSCLC

Warnings

You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing.

What other drugs will affect Vinorelbine

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect vinorelbine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.