Vismodegib

Generic name: Vismodegib
Brand names: Erivedge
Dosage form: oral capsule (150 mg)
Drug class: Hedgehog pathway inhibitors

Usage of Vismodegib

Vismodegib is used in adults to treat basal cell carcinoma that has spread to other parts of the body (metastatic), or that has come back after surgery, or cannot be treated with surgery or radiation.

Vismodegib may also be used for purposes not listed in this medication guide.

Vismodegib side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Vismodegib may cause serious side effects. Call your doctor at once if you have:

muscle spasms or muscle pain.

Vismodegib can affect bone growth in children. Tell your doctor if your child is not growing at a normal rate while using and after stopping vismodegib.

Call your doctor at once if you miss a menstrual period. This could be a side effect, or it may be a sign that you are pregnant.

Common side effects of vismodegib may include:

nausea, vomiting, loss of appetite;

diarrhea, constipation;

tired feeling;

joint pain, muscle spasms;

hair loss;

weight loss; or

decreased sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Vismodegib

You should not use vismodegib if you are allergic to it.

Tell your doctor if you have ever had:

a muscle disorder; or

kidney disease.

Vismodegib can harm an unborn baby if the mother or the father is using vismodegib.

If you are a woman, you will need a pregnancy test within 7 days before starting vismodegib to make sure you are not pregnant. Use birth control while using this medicine and for at least 24 months after your last dose.

If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of vismodegib on the baby.

Do not breastfeed while using this medicine, and for at least 24 months after your last dose.

Relate drugs

How to use Vismodegib

Usual Adult Dose for Basal Cell Carcinoma:

150 mg orally once a day until disease progression or unacceptable toxicityComments:-Withhold therapy for up to 8 weeks for intolerable adverse reactions until improvement or resolution.-Treatment durations shorter than 8 weeks prior to interruptions have not been studied.Use: Treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery and who are not candidates for radiation

Warnings

Do not use if you are pregnant. Both men and women using this medicine should use effective birth control to prevent pregnancy. Vismodegib can harm an unborn baby if the mother or father is using this medicine.

What other drugs will affect Vismodegib

Other drugs may affect vismodegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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