Vizimpro

Generic name: Dacomitinib

Usage of Vizimpro

Vizimpro is a prescription medicine used to treat non-small cell lung cancer that has spread to other parts of the body (metastasised).

Vizimpro is given only if your tumor has a specific genetic marker (an abnormal "EGFR" gene).

It is not known if Vizimpro is safe and effective in children.

Vizimpro side effects

Get emergency medical help if you have signs of an allergic reaction to Vizimpro: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

new or worsening breathing problems (chest pain, wheezing, cough, feeling short of breath);

fever;

severe or ongoing diarrhea;

swelling, redness, or infection under or around your fingernails or toenails; or

a severe skin reaction - dry skin, redness, rash, acne, itching, peeling or blistering.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Vizimpro side effects may include:

diarrhea, loss of appetite;

weight loss;

rash, itching, dry skin;

eye redness, dryness, or itching;

hair loss;

problems with your nails;

mouth sores, mouth pain; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Vizimpro

You may need to have a negative pregnancy test before starting this treatment.

Do not use Vizimpro if you are pregnant.Dacomitinib could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 17 days after your last dose. Tell your doctor if you become pregnant.

Do not breast-feed while using this medicine, and for at least 17 days after your last dose.

To make sure Vizimprois safe for you, tell your doctor if you have ever had:

frequent diarrhea; or

breathing problems (other than lung cancer).

How to use Vizimpro

Usual Adult Dose for Non-Small Cell Lung Cancer:

45 mg orally once a day until disease progression or unacceptable toxicity Use: For the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Vizimpro

Some medicines can make dacomitinib much less effective when taken at the same time. If you take any of the following medicines, take your Vizimpro dose 6 hours before or 10 hours after you take the other medicine:

an antacid; or

a stomach acid reducer (such as Tagamet, Pepcid, Zantac).

Other drugs may interact with dacomitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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