Vonoprazan, amoxicillin, and clarithromycin

Generic name: Vonoprazan, Amoxicillin, And Clarithromycin
Drug class: H. pylori eradication agents

Usage of Vonoprazan, amoxicillin, and clarithromycin

Vonoprazan, amoxicillin, and clarithromycin combination is used to treat patients with H. pylori infection.

Vonoprazan is a potassium-competitive acid blocker (PCAB). It works by decreasing the amount of acid produced by the stomach. Amoxicillin and clarithromycin both belong to the class of medicines known as antibiotics. They work by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Vonoprazan, amoxicillin, and clarithromycin side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Acid or sour stomach

anxiety

belching

black, tarry stools

bladder pain

blistering, crusting, irritation, itching, or reddening of the skin

bloated

bloody or cloudy urine

blurred vision

body aches or pain

change in taste

chest pain or tightness

chills

cold flu-like symptoms

constipation

cracked, dry, or scaly skin

cough or hoarseness

diarrhea

difficult, burning, or painful urination

discouragement

dizziness

dry mouth

ear congestion

excess air or gas in stomach or intestines

eye pain

fainting

fast, pounding, or irregular heartbeat or pulse

feeling sad or empty

fever

frequent urge to urinate

full feeling

general feeling of illness

greatly decreased frequency of urination or amount of urine

headache

heartburn

indigestion

irregular heartbeat recurrent

irritability

itching of the vagina or genitals

lack of appetite

loss of interest or pleasure

loss of taste

loss of voice

lower back or side pain

nausea

nervousness

pain or swelling in the arms or legs without any injury

pale skin

passing gas

pounding in the ears

slow or fast heartbeat

sneezing

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stomach bloating, burning, cramping, discomfort, upset, or pain

stuffy or runny nose

swelling around the eyes

swelling of feet or lower legs

swelling or inflammation of the mouth

thick, white vaginal discharge with mild or no odor

trouble breathing

trouble concentrating

trouble sleeping

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

weight loss

white or brownish vaginal discharge

Rare

Muscle aches

Incidence not known

Black, hairy tongue

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

cold sweats

coma

confusion

confusion about identity, place, and time

coughing up blood

dark urine

diarrhea, watery and severe, which may also be bloody

difficulty swallowing

feeling of unreality

increased menstrual flow or vaginal bleeding

increased thirst

joint or muscle pain

light-colored stools

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle cramps, spasms, pains, or stiffness

nightmares

nosebleeds

pains in stomach, side, or abdomen, possibly radiating to the back

palpitations

paralysis

pinpoint red spots on skin

prolonged bleeding from cuts

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red irritated eyes

red skin lesions, often with a purple center

seizures

sense of detachment from self or body

shakiness

slurred speech

stiff neck or back

swollen glands

tooth discoloration

unpleasant breath odor

vomiting of blood

yellow eyes or skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Vonoprazan, amoxicillin, and clarithromycin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Vozquezna™ Triple Pak™ in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Vozquezna™ Triple Pak™ in the elderly. However, elderly patients are more likely to have kidney problems and heart rhythm problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alfuzosin

Alprazolam

Astemizole

Bepridil

Cisapride

Colchicine

Conivaptan

Dihydroergotamine

Dronedarone

Eletriptan

Eliglustat

Eplerenone

Ergotamine

Finerenone

Flibanserin

Fluconazole

Gepirone

Isavuconazonium Sulfate

Ivabradine

Ketoconazole

Levoketoconazole

Lomitapide

Lovastatin

Lurasidone

Maraviroc

Mavacamten

Mesoridazine

Naloxegol

Nelfinavir

Nimodipine

Pacritinib

Pimozide

Piperaquine

Posaconazole

Ranolazine

Rilpivirine

Saquinavir

Silodosin

Simvastatin

Sparfloxacin

Terfenadine

Thioridazine

Tolvaptan

Ubrogepant

Venetoclax

Voclosporin

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir

Acalabrutinib

Adagrasib

Ado-Trastuzumab Emtansine

Afatinib

Ajmaline

Alfentanil

Amiodarone

Amisulpride

Amitriptyline

Amlodipine

Amobarbital

Amprenavir

Anagrelide

Apalutamide

Apixaban

Apomorphine

Aprepitant

Aprindine

Aprobarbital

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Asenapine

Atazanavir

Atogepant

Atorvastatin

Avacopan

Avanafil

Avapritinib

Axitinib

Azithromycin

Bedaquiline

Benzhydrocodone

Berotralstat

Betrixaban

Bosentan

Bosutinib

Bretylium

Brexpiprazole

Brigatinib

Bromocriptine

Budesonide

Buprenorphine

Buserelin

Butabarbital

Butalbital

Cenobamate

Ceritinib

Chloroquine

Chlorpromazine

Chlortetracycline

Cholera Vaccine, Live

Cilostazol

Ciprofloxacin

Citalopram

Clofazimine

Clomipramine

Clonazepam

Clopidogrel

Clothiapine

Clozapine

Cobicistat

Cobimetinib

Codeine

Copanlisib

Crizotinib

Cyclobenzaprine

Cyclosporine

Dabigatran Etexilate

Dabrafenib

Daclatasvir

Daridorexant

Darunavir

Dasatinib

Deflazacort

Degarelix

Delamanid

Demeclocycline

Desipramine

Deslorelin

Desogestrel

Deutetrabenazine

Dexamethasone

Dexmedetomidine

Dienogest

Digoxin

Dihydrocodeine

Diltiazem

Disopyramide

Docetaxel

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Doxycycline

Droperidol

Drospirenone

Dutasteride

Duvelisib

Ebastine

Edoxaban

Efavirenz

Elacestrant

Elagolix

Elexacaftor

Encorafenib

Entrectinib

Enzalutamide

Eravacycline

Eribulin

Erlotinib

Erythromycin

Escitalopram

Estazolam

Estradiol

Eszopiclone

Ethinyl Estradiol

Ethynodiol

Etrasimod

Etravirine

Everolimus

Famotidine

Fedratinib

Felbamate

Felodipine

Fentanyl

Fesoterodine

Fexinidazole

Fingolimod

Flecainide

Fluoxetine

Fluticasone

Formoterol

Fosaprepitant

Foscarnet

Fosnetupitant

Fosphenytoin

Fostemsavir

Futibatinib

Galantamine

Gatifloxacin

Gemifloxacin

Gestodene

Gilteritinib

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Halothane

Histrelin

Hydrocodone

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibrexafungerp

Ibrutinib

Ibutilide

Idelalisib

Ifosfamide

Iloperidone

Imipramine

Infigratinib

Inotuzumab Ozogamicin

Irinotecan

Irinotecan Liposome

Isoflurane

Isradipine

Istradefylline

Itraconazole

Ivacaftor

Ivosidenib

Ixabepilone

Lapatinib

Larotrectinib

Lefamulin

Lemborexant

Lenacapavir

Leniolisib

Lenvatinib

Letrozole

Leuprolide

Levofloxacin

Levomilnacipran

Levonorgestrel

Lofexidine

Lopinavir

Lorcainide

Lorlatinib

Losartan

Lumacaftor

Lumateperone

Lumefantrine

Lurbinectedin

Lymecycline

Macimorelin

Macitentan

Manidipine

Meclocycline

Mefloquine

Meperidine

Mephobarbital

Mestranol

Methacycline

Methadone

Methohexital

Methotrexate

Metronidazole

Midazolam

Midostaurin

Mifepristone

Minocycline

Mirtazapine

Mirvetuximab Soravtansine-gynx

Mitapivat

Mitotane

Mizolastine

Mobocertinib

Modafinil

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Mycophenolate Mofetil

Nafarelin

Nafcillin

Nelfinavir

Neratinib

Netupitant

Nicardipine

Nifedipine

Nilotinib

Nirmatrelvir

Nisoldipine

Nomegestrol

Norethindrone

Norfloxacin

Norgestimate

Norgestrel

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Ondansetron

Osilodrostat

Osimertinib

Ospemifene

Oxaliplatin

Oxcarbazepine

Oxycodone

Oxytetracycline

Ozanimod

Palbociclib

Paliperidone

Palovarotene

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Pemigatinib

Pentamidine

Pentazocine

Pentobarbital

Perampanel

Perphenazine

Pexidartinib

Phenobarbital

Phenytoin

Pimavanserin

Pipamperone

Pirmenol

Pirtobrutinib

Pitolisant

Pixantrone

Ponatinib

Ponesimod

Pralsetinib

Primidone

Probucol

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Reboxetine

Regorafenib

Relugolix

Retapamulin

Ribociclib

Rifabutin

Rifampin

Rifapentine

Rimegepant

Riociguat

Risperidone

Ritonavir

Rivaroxaban

Roflumilast

Rolitetracycline

Romidepsin

Ruxolitinib

Salmeterol

Sarecycline

Secobarbital

Selpercatinib

Selumetinib

Sertindole

Sertraline

Sevoflurane

Sildenafil

Simeprevir

Siponimod

Sirolimus

Sirolimus Protein-Bound

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sonidegib

Sorafenib

Sotalol

Sparsentan

Spiramycin

St John's Wort

Sufentanil

Sulfamethoxazole

Sulfasalazine

Sulpiride

Sunitinib

Suvorexant

Tacrolimus

Tadalafil

Talazoparib

Tamoxifen

Tamsulosin

Tazemetostat

Telaprevir

Telavancin

Telithromycin

Temsirolimus

Tenofovir Alafenamide

Tetrabenazine

Tetracycline

Tezacaftor

Thiopental

Thiotepa

Ticagrelor

Tigecycline

Tolterodine

Topotecan

Toremifene

Trabectedin

Tramadol

Trazodone

Triazolam

Triclabendazole

Trimethoprim

Trimipramine

Triptorelin

Upadacitinib

Valbenazine

Vamorolone

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Verapamil

Vilanterol

Vilazodone

Vinblastine

Vincristine

Vincristine Sulfate Liposome

Vinflunine

Vinorelbine

Vorapaxar

Voriconazole

Vorinostat

Warfarin

Zaleplon

Zanubrutinib

Zidovudine

Zileuton

Zolpidem

Zuclopenthixol

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol

Cyclosporine

Delavirdine

Diazepam

Glipizide

Glyburide

Hexobarbital

Indinavir

Khat

Linezolid

Methylprednisolone

Nevirapine

Pravastatin

Prednisone

Probenecid

Repaglinide

Rifampin

Tipranavir

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Vonoprazan, amoxicillin, and clarithromycin

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine with or without food.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Take zidovudine at least 2 hours before or after taking Voquezna™ Triple Pak™.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (kit):

For treatment of H. pylori infections:

Adults—20 milligrams (mg) or 1 tablet of vonoprazan, 1000 mg or 2 capsules of amoxicillin, and 500 mg or 1 tablet of clarithromycin 2 times a day for 14 days.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose and it is less than 4 hours, take it as soon as possible. If you miss a dose and it is more than 4 hours, skip the missed dose and take your next dose at the regular time.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, discuss this with your doctor.

Do not use this medicine together rilpivirine (Edurant®) or products containing rilpivirine (eg, Complera®, Odefsey®), dihydroergotamine (Migranal®), ergotamine (Cafergot®), pimozide (Olap®), lomitapide (Juxtapid®), lovastatin (Mevacor®), lurasidone (Latuda®), or simvastatin (Zocor®). Do not use this medicine together with colchicine (Colcrys®) if you have kidney disease or liver disease. Using these medicines together may increase risk for more serious side effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine. If you think you have become pregnant while using the medicine, tell your doctor right away.

Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have chest tightness, rash, itching, fast heartbeat, trouble breathing or swallowing, or large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs while you are using this medicine.

Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. These may be symptoms of serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis (AGEP), toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS).

This medicine may cause hypoglycemia (low blood sugar). This is more common when this medicine is taken together with insulin or oral diabetes medicines. Low blood sugar must be treated before it causes you to pass out (unconsciousness). People feel different symptoms of low blood sugar. It is important that you learn which symptoms you usually have so you can treat it quickly. Talk to your doctor about the best way to treat low blood sugar.

This medicine may cause drowsiness, trouble with thinking, or trouble with controlling body movements when used together with midazolam (Versed®), quetiapine (Seroquel®), or triazolam (Halcion®). Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine may increase the risk of bleeding when used together with a blood thinner (eg, warfarin). Check with your doctor right away if you have bleeding gums, coughing up blood, difficulty in breathing or swallowing, dizziness, headache, increased menstrual flow or vaginal bleeding, nosebleeds, paralysis, prolonged bleeding from cuts, red or dark brown urine, or red or black, tarry stools.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Check with your doctor right away if you have pain or tenderness in the fever with or without chills, upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation and torsade de pointes.

This medicine may cause myasthenia gravis (severe muscle weakness). Check with your doctor right away if you have difficulty in breathing, chewing, swallowing, or talking, double vision, drooping eyelids, muscle weakness, or severe tiredness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St John's wort) or vitamin supplements.

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Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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