Voriconazole (Intravenous)

Generic name: Voriconazole
Drug class: Azole antifungals

Usage of Voriconazole (Intravenous)

Voriconazole injection is used to treat certain serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (including infections in the skin, stomach, kidney, bladder, and wounds). It may also be used to treat patients with serious fungal or yeast infections who cannot tolerate or do not respond to other types of medicine.

This medicine is to be given only by or under the direct supervision of your doctor.

Voriconazole (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

blistering, peeling, loosening of the skin

chest pain

chills

cough

diarrhea

difficulty seeing at night

fever

increased sensitivity of the eyes to sunlight

itching, rash

joint or muscle pain

painful or difficult urination

red irritated eyes

red skin lesions, often with a purple center

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

trouble breathing

unusual bleeding or bruising

unusual tiredness or weakness

vision changes

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

chills

clay-colored stools

confusion

dark urine

decreased urine

dizziness

dry mouth

faintness or lightheadedness when getting up suddenly from a lying or sitting position

feeling of warmth

increased thirst

irregular or pounding heartbeat

loss of appetite

muscle pain or cramps

muscle spasms or twitching

nausea

nervousness

numbness or tingling in the hands, feet, or lips

pounding in the ears

rapid weight gain

rash with flat lesions or small raised lesions on the skin

redness of the face, neck, arms, and occasionally, the upper chest

seizures

slow or fast heartbeat

stomach pain

sweating

trembling

unpleasant breath odor

vomiting of blood

yellow eyes or skin

Rare

Black, bloody, or tarry stools

bleeding gums

blood in the eye

blood in the urine or stools

eye pain

pale skin

pinpoint red spots on the skin

redness in the white part of the eyes

seeing things that are not there

Incidence not known

Backache

blindness

blue-yellow color blindness

bone pain

chapped, red, or swollen lips

darkening of the skin

decreased vision

diarrhea

facial hair growth in females

fainting

fractures

full or round face, neck, or trunk

increased urination

irritability

loss of sexual desire or ability

menstrual irregularities

mental depression

muscle wasting

scaling, redness, burning, pain, or other signs of inflammation of the lips

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Headache

pain or swelling at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Voriconazole (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of voriconazole injection in children younger than 2 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of voriconazole injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alprazolam

Astemizole

Atazanavir

Bepridil

Carbamazepine

Cisapride

Colchicine

Conivaptan

Dihydroergotamine

Dronedarone

Efavirenz

Eletriptan

Eliglustat

Eplerenone

Ergoloid Mesylates

Ergonovine

Ergotamine

Finerenone

Flibanserin

Fluconazole

Gepirone

Isavuconazonium Sulfate

Ivabradine

Levoketoconazole

Lomitapide

Lovastatin

Lurasidone

Maraviroc

Mavacamten

Mephobarbital

Mesoridazine

Methylergonovine

Methysergide

Naloxegol

Nelfinavir

Nimodipine

Nirmatrelvir

Pacritinib

Phenobarbital

Pimozide

Piperaquine

Posaconazole

Primidone

Quinidine

Rifabutin

Rifampin

Ritonavir

Saquinavir

Simvastatin

Sirolimus

Sparfloxacin

St John's Wort

Terfenadine

Thioridazine

Tolvaptan

Ubrogepant

Venetoclax

Voclosporin

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib

Acenocoumarol

Adagrasib

Ado-Trastuzumab Emtansine

Afatinib

Alectinib

Alfentanil

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Apalutamide

Apixaban

Apomorphine

Aprepitant

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Asenapine

Atogepant

Atorvastatin

Avacopan

Avanafil

Avapritinib

Axitinib

Azithromycin

Baricitinib

Bedaquiline

Belzutifan

Benzhydrocodone

Boceprevir

Bosutinib

Brentuximab Vedotin

Bretylium

Brexpiprazole

Brigatinib

Bromocriptine

Budesonide

Buprenorphine

Buserelin

Carvedilol

Ceritinib

Chloramphenicol

Chloroquine

Chlorpromazine

Cilostazol

Ciprofloxacin

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clothiapine

Clozapine

Cobicistat

Cobimetinib

Codeine

Copanlisib

Crizotinib

Cyclobenzaprine

Cyclosporine

Dabrafenib

Daclatasvir

Daridorexant

Darunavir

Dasabuvir

Dasatinib

Deflazacort

Degarelix

Delamanid

Delavirdine

Desipramine

Deslorelin

Deutetrabenazine

Dexamethasone

Dexmedetomidine

Dicumarol

Dihydrocodeine

Disopyramide

Docetaxel

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Duvelisib

Elacestrant

Elagolix

Elexacaftor

Elvitegravir

Encorafenib

Entacapone

Entrectinib

Enzalutamide

Erlotinib

Erythromycin

Escitalopram

Eslicarbazepine Acetate

Eszopiclone

Etrasimod

Everolimus

Fedratinib

Fentanyl

Fesoterodine

Fexinidazole

Fingolimod

Flecainide

Fluoxetine

Fluticasone

Formoterol

Fosaprepitant

Foscarnet

Fosphenytoin

Fostamatinib

Fostemsavir

Gatifloxacin

Gefitinib

Gemifloxacin

Gilteritinib

Glasdegib

Glimepiride

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Histrelin

Hydrocodone

Hydroxychloroquine

Hydroxyzine

Ibrexafungerp

Ibrutinib

Ibutilide

Idelalisib

Ifosfamide

Iloperidone

Imipramine

Infigratinib

Inotuzumab Ozogamicin

Irinotecan

Irinotecan Liposome

Istradefylline

Ivacaftor

Ivosidenib

Ixabepilone

Ketoconazole

Lansoprazole

Lapatinib

Larotrectinib

Lefamulin

Lemborexant

Leniolisib

Lenvatinib

Letermovir

Leuprolide

Levofloxacin

Levomilnacipran

Lofexidine

Lopinavir

Lorlatinib

Lumacaftor

Lumateperone

Lumefantrine

Lurbinectedin

Macimorelin

Macitentan

Manidipine

Mefloquine

Meperidine

Methadone

Methotrexate

Methylprednisolone

Metronidazole

Midostaurin

Mifepristone

Mirtazapine

Mirvetuximab Soravtansine-gynx

Mitapivat

Mobocertinib

Moxifloxacin

Nafarelin

Neratinib

Nevirapine

Nifedipine

Nilotinib

Nintedanib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Ombitasvir

Omeprazole

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Oxycodone

Ozanimod

Palbociclib

Paliperidone

Palovarotene

Panobinostat

Paritaprevir

Paroxetine

Pasireotide

Pazopanib

Pemigatinib

Pentazocine

Pexidartinib

Phenprocoumon

Phenytoin

Pimavanserin

Pirtobrutinib

Pitolisant

Ponatinib

Ponesimod

Pralsetinib

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinine

Quizartinib

Ranolazine

Reboxetine

Regorafenib

Relugolix

Retapamulin

Ribociclib

Rimegepant

Rivaroxaban

Romidepsin

Ruxolitinib

Salmeterol

Selpercatinib

Selumetinib

Sertraline

Sevoflurane

Sildenafil

Simeprevir

Siponimod

Sirolimus Protein-Bound

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sonidegib

Sorafenib

Sotalol

Sparsentan

Sufentanil

Sulpiride

Sunitinib

Suvorexant

Tacrolimus

Tadalafil

Tamsulosin

Tazemetostat

Telaprevir

Telavancin

Telithromycin

Temsirolimus

Tetrabenazine

Tezacaftor

Thiotepa

Ticagrelor

Toremifene

Trabectedin

Tramadol

Trazodone

Triazolam

Triclabendazole

Trifluoperazine

Trimipramine

Triptorelin

Tucatinib

Upadacitinib

Valbenazine

Vamorolone

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Vilanterol

Vilazodone

Vinblastine

Vincristine

Vincristine Sulfate Liposome

Vinflunine

Vinorelbine

Vorapaxar

Warfarin

Zanubrutinib

Zolpidem

Zuclopenthixol

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine

Amprenavir

Cerivastatin

Desogestrel

Dienogest

Drospirenone

Esomeprazole

Estetrol

Estradiol

Ethinyl Estradiol

Ethynodiol

Etravirine

Fosamprenavir

Gestodene

Glipizide

Glyburide

Levonorgestrel

Meloxicam

Mestranol

Midazolam

Nomegestrol

Norethindrone

Norgestimate

Norgestrel

Tolbutamide

Tretinoin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Voriconazole (Intravenous)

A nurse or other trained health professional will give you or your child this medicine. It is given through a needle placed into one of your veins. It must be given slowly, so your IV tube should stay in place for up to 2 hours.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Warnings

It is very important that your doctor check you or your child closely while you are receiving this medicine. This is to make sure that this medicine is working properly. Blood and urine tests will be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days or if they become worse, check with your doctor.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

You or your child should not use astemizole (Hismanal®), barbiturates (eg, phenobarbital, Luminal®), carbamazepine (Tegretol®), efavirenz (Sustiva®), ergot medicines (eg, dihydroergotamine, ergotamine, Cafergot®, Ergomar®, Wigraine®), ivabradine (Corlanor®, Procoralan®), lemborexant (Dayvigo®), lurasidone (Latuda®), naloxegol (Movantik®), pimozide (Orap®), quinidine (Quinaglute®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), sirolimus (Rapamune®), St. John's wort, terfenadine (Seldane®), tolvaptan (Jynarque®, Samsca®), or venetoclax (Venclexta®). Using any of them together with this medicine may increase the chance of unwanted effects.

This medicine may cause some people to have changes in vision, including blurred vision and seeing bright spots or wavy lines. Do not drive (especially at night) or do anything else that could be dangerous until you know how this medicine affects you.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you or your child have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem, including QT prolongation.

This medicine may cause a serious type of allergic reaction, called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child have a fever, chills, flushing, itching or skin rash, sweating, trouble breathing, lightheadedness, fainting, or chest tightness within a few hours after you receive it.

This medicine may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS). Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, painful or difficult urination, swollen glands. trouble breathing, unusual bleeding, bruising, tiredness, or weakness.

Voriconazole may increase your or your child's risk of having kidney problems, including acute kidney failure. Check with your doctor right away if you have blood in the urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, decreased awareness or responsiveness, severe sleepiness, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

Pancreatitis (swelling of the pancreas) may occur while you or your child are receiving this medicine. Check with your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

This medicine may make your skin more sensitive to sunlight when used together with methotrexate (Reditrex®). Use sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

This medicine may cause adrenal gland problems. Check with your doctor right away if you or your child have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause bone pain when used for a long period of time. Check with your doctor right away if you or your child have bone pain while receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.