Vorinostat

Generic name: Vorinostat
Brand names: Zolinza
Dosage form: oral capsule (100 mg)
Drug class: Histone deacetylase inhibitors

Usage of Vorinostat

Vorinostat is used to treat skin problems caused by cutaneous T-cell lymphoma.

Vorinostat is usually given after other treatments did not work or have stopped working.

Vorinostat may also be used for purposes not listed in this medication guide.

Vorinostat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Vorinostat may cause serious side effects. Call your doctor at once if you have:

  • dehydration symptoms--dizziness, drowsiness, feeling very thirsty or hot, being unable to urinate, hot and dry skin;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
  • low platelets or red blood cells--pale skin, easy bruising, unusual bleeding, purple or red spots under your skin, unusual tiredness, feeling light-headed, cold hands and feet;
  • signs of a blood clot in the lung--chest pain, fast heartbeats, shortness of breath, sweating, coughing up blood; or
  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.

    • Common side effects of vorinostat may include:

  • nausea, vomiting, loss of appetite;
  • diarrhea, constipation;
  • weight loss;
  • swelling in your lower legs;
  • dry mouth;
  • fever, chills, headache, muscle pain;
  • cold symptoms such as stuffy nose, sneezing, cough.
  • dizziness, tiredness;
  • itching, hair loss; or
  • altered sense of taste.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Vorinostat

    Tell your doctor if you have ever had:

  • diabetes or high blood sugar;
  • a blood clot;
  • liver disease;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • any allergies.

    • Vorinostat can harm an unborn baby if the mother or the father is using vorinostat.

  • If you are a woman, do not use vorinostat if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using vorinostat.

    • Do not breast-feed while using this medicine, and for at least 1 week after your last dose.

    Relate drugs

    How to use Vorinostat

    Usual Adult Dose for Cutaneous T-cell Lymphoma:

    400 mg orally once a day; If a patient is intolerant to therapy, the dose may be reduced to 300 mg orally once daily; the dose may be further reduced to 300 mg once daily for 5 consecutive days each week if needed-This drug should be taken with food.-Swallow capsules whole; do not open or crush.-Therapy may be continued as long as there is no evidence of progressive disease or unacceptable toxicity.Use: For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent, or recurrent disease on or following 2 systemic therapies

    Warnings

    Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

    What other drugs will affect Vorinostat

    Tell your doctor about all your other medicines, especially:

  • valproic acid; or
  • a blood thinner (warfarin, Coumadin, Jantoven).

    • This list is not complete. Other drugs may affect vorinostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Disclaimer

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