Vosoritide

Generic name: Vosoritide
Brand names: Voxzogo
Dosage form: subcutaneous powder for injection (0.4 mg; 0.56 mg; 1.2 mg)
Drug class: Miscellaneous hormones

Usage of Vosoritide

Vosoritide is used to help in growth in children with achondroplasia (a type of rare genetic bone disorder) who are 5 years and older whose bones are still growing.

Vosoritide may also be used for purposes not listed in this medication guide.

Vosoritide side effects

Get emergency medical help if your child has signs of an allergic reaction: hives; difficult breathing; swelling of the face, lips, tongue, or throat.

Your child's blood pressure may get low. Your child should eat a meal and drink about 8 to 10 ounces of fluid within 1 hour before receiving vosoritide.

Common side effects of vosoritide may include:

pain, bruising, swelling, or irritation where the medicine was injected;

vomiting, stomach pain;

joint pain; or

dizziness, tiredness, or nausea.

This is not a complete list of side effects and others may occur. Call the doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Vosoritide

Tell the doctor if your child has:

kidney problems.

Tell the doctor if your teenage child is pregnant or breastfeeding.

Talk to the doctor about the best way to feed your child's baby if your child is using vosoritide.

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How to use Vosoritide

Usual Pediatric Dose for Achondroplasia:

Administer by suBCutaneous injection once daily.5 years or older:-Weight 10 to 11 kg: 0.24 mg subcutaneously once a day-Weight 12 to 16 kg: 0.28 mg subcutaneously once a day-Weight 17 to 21 kg: 0.32 mg subcutaneously once a day-Weight 22 to 32 kg: 0.4 mg subcutaneously once a day-Weight 33 to 43 kg: 0.5 mg subcutaneously once a day-Weight 44 to 59 kg: 0.6 mg subcutaneously once a day-Weight 60 to 89 kg: 0.7 mg subcutaneously once a day-Weight at least 90 kg: 0.8 mg subcutaneously once a dayComments:-The recommended dosage is based on the patient's actual body weight.-This drug should be administered at about the same time each day, if possible.-Patient body weight, growth, and physical development should be monitored and assessed regularly every 3 to 6 months; dosage should be adjusted according to patient's actual body weight.-This drug should be permanently discontinued upon confirmation of no further growth potential, indicated by closure of epiphyses.Use: To increase linear growth in patients with achondroplasia who are 5 years of age and older with open epiphyses

Warnings

Use only as directed. Tell the doctor if your child uses other medicines or has other medical conditions or allergies.

What other drugs will affect Vosoritide

Other drugs may affect vosoritide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell the doctor about all other medicines your child uses.

Disclaimer

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