Voxelotor

Generic name: Voxelotor
Brand names: Oxbryta
Drug class: Miscellaneous uncategorized agents

Usage of Voxelotor

Voxelotor is used to treat sickle cell disease in adults and children at least 4 years old.

Voxelotor is sometimes given together with another medicine called hydroxyurea.

Voxelotor may also be used for purposes not listed in this medication guide.

Voxelotor side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of voxelotor may include:

headache;

fever;

hives, rash; or

stomach pain, nausea, diarrhea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Voxelotor

You should not use voxelotor if you are allergic to it.

Tell your doctor if you have ever had:

liver problems.

It is not known if voxelotor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using voxelotor, and for at least 2 weeks after your last dose.

Relate drugs

How to use Voxelotor

Usual Adult Dose for Sickle Cell Anemia:

1500 mg orally once a dayComment:-This drug may be given with or without hydroxyurea. Use: For the treatment of sickle cell disease.

Usual Pediatric Dose for Sickle Cell Anemia:

4 to less than 12 years: -Weight: 10 to less than 20 kg: 600 mg orally once a day-Weight: 20 to less than 40 kg: 900 mg orally once a day -Weight 40 kg or greater: 1500 mg orally once a day 12 years or older: 1500 mg orally once a dayComment:-This drug may be given with or without hydroxyurea. Use: For the treatment of sickle cell disease in patients 4 years or older.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What other drugs will affect Voxelotor

Tell your doctor about all your current medicines. Many drugs can affect voxelotor, especially:

phenobarbital or other barbiturate medicine;

St. John's wort;

an antibiotic--rifabutin, rifampin, rifapentine;

cancer medicine--apalutamide, enzalutamide, mitotane;

HIV or AIDS medicine--efavirenz, nevirapine;

seizure medicine--Carbamazepine, oxcarbazepine, phenytoin, primidone; or

steroid medicine--dexamethasone, prednisone.

This list is not complete and many other drugs may affect voxelotor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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