Vumerity

Generic name: Diroximel Fumarate
Drug class: Selective immunosuppressants

Usage of Vumerity

Vumerity is a prescription medicine used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).

Exactly how Vumerity works in treating multiple sclerosis is not known.

It is not known if Vumerity is safe and effective in children.

Vumerity side effects

Get emergency medical help if you have signs of an allergic reaction to Vumerity: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Diroximel fumarate may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Call your doctor at once if you have signs of liver problems, such as:

right-sided upper stomach pain;

loss of appetite;

tiredness;

dark urine; or

jaundice (yellowing of the skin or eyes).

Common Vumerity side effects may include:

indigestion, nausea, vomiting, stomach pain;

diarrhea; or

flushing (sudden warmth, redness, or tingly feeling);

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Vumerity

You should not use Vumerity if:

you have had a severe allergic reaction to diroximel fumarate or dimethyl fumarate (Tecfidera); or

you also use dimethyl fumarate.

To make sure Vumerity is safe for you, tell your doctor if you have ever had:

liver disease;

kidney disease;

infections; or

low white blood cell (WBC) counts.

Tell your doctor if you are pregnant or breastfeeding.

Vumerity is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Vumerity

Usual Adult Dose for Multiple Sclerosis:

Initial dose: 231 mg orally 2 times a day for 7 days, then increase to 462 mg orally 2 times a day Maintenance dose: 462 mg orally 2 times a day; temporary dose reductions to 231 mg 2 times a day may be considered for individuals who do not tolerate the maintenance dose; within 4 weeks the recommended dose of 462 mg 2 times a day should be resumed; consider discontinuing therapy in patients unable to tolerate return to the maintenance dose Comments: -Administration of nonenteric coated aspirin (up to 325 mg) 30 minutes prior to this drug may reduce the incidence/severity of flushing. Use: For the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease

Warnings

You should not use Vumerity if you have had a severe allergic reaction to diroximel fumarate, or if you also use dimethyl fumarate (Tecfidera).

What other drugs will affect Vumerity

Other drugs may interact with diroximel fumarate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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