Wynzora
Generic name: Calcipotriene And Betamethasone Dipropionate
Dosage form: cream
Drug class:
Topical antipsoriatics
Usage of Wynzora
Wynzora is a once-daily, topical, fixed-dose combination cream containing Calcipotriene 0.005% (a vitamin D analog) and Betamethasone dipropionate 0.064% (a corticosteroid) that may be used to treat plaque psoriasis in adults 18 years of age or older.
The cream uses PAD™ Technology, which enables the mixing of oil and water using just a fraction of the emulsifier required in conventional creams and lotions. This improves the penetration, solubility, and stability of the active ingredients, the tolerability of the product, and makes it more convenient to use.
Wynzora was approved on July 22, 2020.
Wynzora side effects
The most common side effects reported with Wynzora include upper respiratory tract infections, headaches, and irritation at the application site.
Postmarketing studies with topical corticosteroids have reported atrophy, striae, telangiectasias, itching, dryness, hypopigmentation, perioral dermatitis, secondary infection, and miliaria.
Ophthalmic adverse Reactions of cataracts, glaucoma, and increased intraocular pressure, have been reported during the use of topical corticosteroids, including topical betamethasone products.
Before taking Wynzora
You should not use Wynzora cream if you are allergic to calcipotriene, Betamethasone dipropionate, or any other components of the cream.
Tell your doctor if you have ever had:
Relate drugs
- Ammoniated mercury
- Anthralin
- Betamethasone and calcipotriene
- Betamethasone and calcipotriene topical
- Calcipotriene
- Calcipotriene topical
- Calcitrene
- Calcitriol topical
- DiabetAid Anti-Itch
- Dovonex
- Dritho-Scalp
- Drithocreme
- Duobrii
- Enstilar
- Halobetasol and tazarotene
- Halobetasol and tazarotene topical
- Psoriatec
- R A Acne topical
- Resinol topical
- Resorcinol
- Resorcinol topical
- Sorilux
- Taclonex
- Taclonex Scalp
- Tapinarof
- Vectical
- Vtama
- Wynzora
- Zithranol
- Zithranol-RR
How to use Wynzora
Wynzora should be applied once daily to the plaques for up to 8 weeks. Rub in gently to ensure the plaques are saturated.
Warnings
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
Hypercalcemia and hypercalciuria have been observed with the use of topical calcipotriene. If either occurs, discontinue Wynzora until laboratory values of calcium normalize.
Endocrine effects
The use of high-potency steroid creams such as betamethasone dipropionate can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency during and after withdrawal of treatment. Risk factors include the use of high-potency topical corticosteroids, use over a large surface area, or to areas under occlusion, prolonged use, altered skin barrier, liver failure, and young age. Modify use should HPA axis suppression develop.
Ophthalmic Adverse Reactions
May increase the risk of cataracts and glaucoma. If visual symptoms occur, consider referral to an ophthalmologist.
Allergic contact dermatitis
May occur with either calcipotriene or betamethasone dipropionate topical use. May be observed as a failure to heal. COnfirm with diagnostic patch testing.
Pregnancy
Use of high-potency topical steroid medicine during pregnancy may increase the risk of a low birth weight in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Lactation
It may not be safe to breastfeed while using Wynzora. Ask your doctor about any risks. If you apply Betamethasone and calcipotriene to your chest, avoid areas that may come into contact with the baby's mouth.
Children
Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects. Wynzora is not approved for use by anyone younger than 18 years old.
What other drugs will affect Wynzora
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect betamethasone and calcipotriene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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