Xenleta oral/injection

Generic name: Lefamulin (oral/injection)
Brand names: Xenleta
Drug class: Miscellaneous antibiotics

Usage of Xenleta oral/injection

Xenleta is used to treat certain types of pneumonia in adults.

Xenleta may also be used for purposes not listed in this medication guide.

Xenleta oral/injection side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Xenleta may cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); or

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of Xenleta may include:

nausea, vomiting, diarrhea;

sleep problems (insomnia);

low potassium;

headache;

abnormal liver function tests; or

pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Xenleta oral/injection

You should not use Xenleta if you are allergic to it.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with Xenleta. Your doctor may change your treatment plan if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor if you have ever had:

a heart rhythm disorder (especially if you take medication to treat it);

long QT syndrome;

liver disease; or

kidney disease (or if you are on dialysis).

You may need to have a negative pregnancy test before starting this treatment.

Xenleta may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Xenleta and for at least 2 days after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed within 2 days after using Xenleta. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

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How to use Xenleta oral/injection

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Xenleta oral is taken by mouth.

Take Xenleta oral on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take Xenleta oral with a full glass (6 to 8 ounces) of water. Swallow the tablet whole and do not crush, chew, or break it.

Xenleta injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Xenleta injection must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Xenleta injection must be given slowly, and the infusion can take about 60 minutes to complete.

You will need frequent blood tests to check your liver function.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Xenleta will not treat a viral infection such as the flu or a common cold.

Store the tablets at room temperature away from moisture and heat.

Store Xenleta injection in the refrigerator, do not freeze. Store the diluent bags at room temperature.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

After mixing Xenleta injection with the diluent, you may store the mixture for up to 24 hours at room temperature, or up to 48 hours in a refrigerator.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What other drugs will affect Xenleta oral/injection

Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Xenleta can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect Xenleta. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.