Xiidra

Generic name: Lifitegrast Ophthalmic Solution 5%
Dosage form: Eye drops
Drug class: Ophthalmic anti-inflammatory agents

Usage of Xiidra

Xiidra (lifitegrast 5%) is an eye drop solution that is used twice daily in each eye to treat the signs and symptoms of dry eye disease (DED) in adults over the age of 17 years.

Xiidra works by preventing a certain protein called lymphocyte function-associated antigen-1 (LFA-1) on the surface of leukocytes (a type of blood cell), from binding to a type of adhesion molecule called ICAM-1 which may be overexpressed in corneal and conjunctival tissues in people with DED. The interaction between LFA-1 and ICAM-1 is associated with T-cell activation and migration and the secretion of inflammatory cytokines. By blocking this interaction, Xiidra may prevent the secretion of inflammatory cytokines which improves the symptoms of DED, although the exact way it works in DED is not known.

Xiidra was FDA approved on July 11, 2016.

Xiidra side effects

Get emergency medical help if you have signs of an allergic reaction to Xiidra, such as hives; difficulty breathing; or swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

vision problems; or

severe eye redness or irritation.

Common Xiidra side effects may include:

blurred vision;

eye discomfort;

eye irritation;

unusual or unpleasant taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Xiidra

Before you use Xiidra, tell your doctor if you:

are using any other eye drops

wear contact lenses

are pregnant or plan to become pregnant. It is not known if Xiidra will harm your unborn baby

are breastfeeding or plan to breastfeed. It is not known if Xiidra passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use Xiidra.

Xiidra is not approved for use by anyone younger than 17 years old.

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How to use Xiidra

Wash your hands before using the eye drops.

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

Instil one drop of Xiidra into each eye twice daily (approximately 12 hours apart).

Close your eyes for 2 or 3 minutes with your head level, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the Xiidra eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Each container of Xiidra is for single use only. Throw away the container after putting the drops in each eye, even if some solution remains.

If you wear contact lenses, remove them before putting Xiidra drops into your eyes. You can reinsert them 15 minutes later.

Use Xiidra exactly as directed by your healthcare provider. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Warnings

There are no contraindications to the use of Xiidra.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Xiidra

It is not likely that other drugs will interact with Xiidra. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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