Xospata
Generic name: Gilteritinib
Drug class:
Multikinase inhibitors
Usage of Xospata
Xospata is a prescription medicine used to treat acute myeloid leukemia (AML) in adults with an abnormal FLT3 gene. Your doctor will test you for this gene.
Xospata is given after other cancer treatments did not work or have stopped working.
It is not known if Xospata is safe and effective in children.
Xospata side effects
Get emergency medical help if you have signs of an allergic reaction to Xospata: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Gilteritinib can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 2 days to 3 months after you start taking Xospata.
Seek medical help right away if you have symptoms of differentiation syndrome:
Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Xospata side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Xospata
You should not use Xospata if you are allergic to gilteritinib.
To make sure Xospata is safe for you, tell your doctor if you have ever had:
Before you take this medicine, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Gilteritinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
Do not breastfeed while using this medicine, and for at least 2 months after your last dose.
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How to use Xospata
Usual Adult Dose for Acute Myeloid Leukemia:
120 mg orally once a day until disease progression or unacceptable toxicity Comments: -Response may be delayed. In the absence of disease progression or unacceptable toxicity, patients should be treated for a minimum of 6 months to allow time for a clinical response. -Select patients for the treatment of AML with this drug based on the presence of FLT3 mutations in the blood or bone marrow. Use: For the treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FMS-like tyrosine kinase 3 (FLT3) mutation as detected by an FDA-approved test.
Warnings
Do not take Xospata if you are allergic to gilteritinib or any of its inactive ingredients which include: mannitol, hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose, magnesium stearate, hypromellose, talc, polyethylene glycol, titanium dioxide and ferric oxide.
Xospata can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 2 days to 3 months after you start taking Xospata.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, cough, trouble breathing, bone pain, rapid weight gain, or swelling in your arms, legs, underarms, groin, or neck.
What other drugs will affect Xospata
Other drugs may interact with gilteritinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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