Xphozah

Generic name: Tenapanor
Dosage form: tablet (10mg, 20mg, 30mg)
Drug class: NHE3 inhibitors

Usage of Xphozah

Xphozah is a phosphate absorption inhibitor that is used to lower serum phosphorus levels for patients with chronic kidney disease (CKD) on dialysis who have tried phosphate binders but they have worked well enough, or they are unable to take them. Xphozah is a twice a daily tablet that works by blocking phosphate absorption in the gut to help return phosphate to normal serum levels. Xphozah is the first and only phosphate absorption inhibitor that has been approved by the Food and Drug Administration (FDA).

Xphozah (tenapanor) became an FDA-approved medication on Oct. 17, 2023, after positive results from three Phase 3 clinical trials (PHREEDOM, BLOCK, and AMPLIFY) showing Xphozah significantly reduced high serum phosphorus in patients receiving maintenance hemodialysis. Xphozah is FDA-approved to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or are intolerant of any dose of phosphate binder therapy.

Results from the three clinical trials showed that Xphozah significantly reduced elevated serum phosphorus in patients who were on maintenance hemodialysis.

Xphozah side effects

The most common Xphozah side effect was diarrhea which affected 43-53% of patients with CKD in clinical trials. Most of the diarrhea events were reported to be mild-to-moderate in severity and did resolve over time or with dose reduction. Diarrhea was usually reported soon after starting treatment but could occur at any time during treatement. Severe diarrhea was reported in 5% of Xphozah-treated patients in these trials.

Before taking Xphozah

You should not take Xphozah if:

you have known or suspected mechanical gastrointestinal obstruction

Relate drugs

How to use Xphozah

Usual adult Xphozah dose is a single tablet taken twice daily.

Xphozah is available as 10mg, 20mg, and 30mg tablets.

If a dose is missed, skip the missed dose and take the next dose at the regular time. Do not take 2 doses at the same time.

Xphozah is indicated for adult use.

Warnings

Diarrhea. Patients using Xphozah may experience severe diarrhea. Treatment with this medicine should be discontinued in patients who develop severe diarrhea.

What other drugs will affect Xphozah

Tell your doctor about all your current medicines and any you start or stop using, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The active ingredient of Xphozah is Tenapanor which is an inhibitor of intestinal uptake transporter, OATP2B1. There is potential for reduced exposure to the concomitant drug (e.g., enalapril). Monitor for signs related to loss of efficacy and adjust the dosage of the concomitantly administered drug as needed.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.